摘要
目的观察益肾化瘀通络汤对脑梗死后血管性痴呆患者行为认知功能、情绪状态及睡眠质量的影响。方法选择2019年6月至2020年6月我院收治的100例脑梗死后血管性痴呆患者为研究对象,依据随机数字表法将其分为对照组和观察组,各50例。对照组以常规西药治疗,观察组在对照组基础上联合益肾化瘀通络汤治疗。比较两组的临床疗效;比较两组治疗前、后的血清学指标、行为认知功能、情绪状态、睡眠质量。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组的MMP-9、LpPLA2水平均降低,BDNF水平均升高,且观察组优于对照组(P<0.05)。治疗后,两组的ADL、MMSE、IMCT评分均升高,BBS评分均降低,且观察组优于对照组(P<0.05)。治疗后,两组的HAMA、HAMD、PSQI评分均降低,且观察组低于对照组(P<0.05)。结论在常规西药治疗基础上联合益肾化瘀通络汤治疗脑梗死后血管性痴呆患者的效果显著,可改善血清学指标水平,促进患者行为认知功能及情绪状态恢复,提高睡眠质量,值得临床推广。
Objective To observe the effects of Yishen Huayu Tongluo decoction on behavioral cognitive function,emotional state and sleep quality of patients with vascular dementia after cerebral infarction.Methods A total of 100 patients with vascular dementia after cerebral infarction admitted in our hospital from June 2019 to June 2020 were selected as the research objects and divided into control group and observation group according to random number table method,with 50 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Yishen Huayu Tongluo decoction on the basis of the control group.The clinical efficacy of the two groups was compared;the serological indexes,behavioral cognitive function,emotional state and sleep quality of the two groups were compared before and after treatment.Results The total effective rate of treatment of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of MMP-9,LpPLA2 in the two groups decreased,the level of BDNF increased,and those in the observation group were better than the control group(P<0.05).After treatment,the scores of ADL,MMSE and IMCT in the two groups increased,and the BBS score decreased,and those in the observation group were better than the control group(P<0.05).After treatment,HAMA,HAMD and PSQI scores in both groups decreased,and those in the observation group were lower than the control group(P<0.05).Conclusion On the basis of conventional western medicine treatment,combined Yishen Huayu Tongluo decoction in the treatment of patients with vascular dementia after cerebral infarction has a significant effect,it can ameliorate the levels of serological indexes,promote the recovery of behavioral cognitive function and emotional state,and improve sleep quality,which is worthy of clinical promotion.
作者
胡金莲
于海峰
HU Jinlian;YU Haifeng(Ninth Hospital of Xi'an,Xi'an 710054;People's Hospital of Tongchuan,Tongchuan 727100,China)
出处
《临床医学研究与实践》
2022年第12期134-137,共4页
Clinical Research and Practice
关键词
益肾化瘀通络汤
脑梗死
血管性痴呆
行为认知功能
血清学指标
睡眠质量
Yishen Huayu Tongluo decoction
cerebral infarction
vascular dementia
behavioral cognitive function
serological index
sleep quality
