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异常糖链糖蛋白及CA199与早期胃癌及癌前病变的相关性

Correlations of abnormal globular chain glycoprotein and CA199 with early gastric cancer and precancerous lesions
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摘要 目的探讨异常糖链糖蛋白(TAP)及CA199与早期胃癌及癌前病变的相关性。方法选取2020年1月至2021年1月重庆市开州区人民医院收治的60例早期胃癌及癌前病变患者作为研究对象,依照患者的癌变程度进行分组。其中早期胃癌患者36例作为早期胃癌组,癌前病变24例作为癌前病变组。另选择30名健康者作为对照组,对比三组受试者异常糖链糖蛋白及CA199表达水平。并分析TAP与CA199阳性患者与阴性患者各病理表达情况,最终分析异常糖链糖蛋白及CA199与早期胃癌及癌前病变病理的相关性。结果早期胃癌组TAP平均面积为(126.69±25.75)μm^(2),癌前病变组为(89.80±21.82)μm^(2),对照组为(79.57±13.24)μm^(2),早期胃癌组、癌前病变组与对照组比较,差异有统计学意义(P<0.05),早期胃癌组CA199为(62.62±12.21)U/ml,癌前病变组为(42.51±10.02)U/ml,对照组为(15.04±3.13)U/ml,早期胃癌组、癌前病变组与对照组比较,差异有统计学意义(P<0.05);通过染色检测发现60例早期胃癌与癌前病变患者中TAP阳性患者41例,阴性患者19例,CA199阳性患者45例,阴性患者15例;TAP阳性表达与阴性表达患者的性别、年龄、淋巴结节转移情况比较,差异无统计学意义(P>0.05),TAP阳性患者肿瘤>5 cm、TNM分期为Ⅰ~Ⅱ期、肿瘤分化程度为中分化的分别为29例、26例、26例,高于TAP阴性患者,差异有统计学意义(P<0.05);CA199阳性表达与阴性表达患者的性别、年龄、肿瘤大小、TNM分期、淋巴结节转移情况比较,差异无统计学意义(P>0.05),CA199阳性患者肿瘤分化程度为中分化的为38例,高于CA199阴性患者,差异有统计学意义(P<0.05);Spearman相关分析结果显示,早期胃癌及癌前病变患者的TNM分期、肿瘤分化程度与TAP表达呈正相关(P<0.05),早期胃癌及癌前病变患者的肿瘤分化程度与CA199表达呈正相关(P<0.05)。结论异常糖链糖蛋白及CA199与早期胃癌及癌前病变具有一定相� Objective To investigate the correlations of abnormal globular chain glycoprotein(TAP)and CA199 with early gastric cancer and precancerous lesions.Methods A total of 60 patients with early gastric cancer and precancerous lesions admitted to People’s Hospital of Kaizhou District in Chongqing from January 2020 to January 2021 were selected.According to degree of cancer,they were divided into the early gastric cancer group and the precancerous lesion group,with 36 and 24 patients,respectively.Another 30 healthy people were selected as the control group.The expression levels of abnormal globular chain glycoprotein and CA199 were compared among the three groups.The pathological expressions of TAP and CA199 positive patients and negative patients were analyzed to investigate the correlations of abnormal globular chain glycoprotein and CA199 with pathology of early gastric cancer and precancerous lesions.Results The average area of TAP was(126.69±25.75)μm^(2) in the early gastric cancer group,(89.80±21.82)μm^(2) in the precancerous lesion group,and(79.57±13.24)μm^(2) in the control group,with statistically significant differences(P<0.05).The CA199 was(62.62±12.21)U/ml in the early gastric cancer group,(42.51±10.02)U/ml in the precancerous lesion group,and(15.04±3.13)U/ml in the control group,with statistically significant differences(P<0.05).Among the 60 patients with early gastric cancer and precancerous lesions,there were 41 TAP positive patients and 19 TAP negative patients,and 45 CA199 positive patients and 15 CA199 negative patients.There were no significant differences in gender,age,and lymph node metastasis between TAP positive and negative patients(P>0.05).There were 29 patients with tumor size>5 cm,26 patients with TNM staging as stageⅠ-Ⅱ,and 26 patients with moderate tumor differentiation in TAP positive patients,which were more than those in TAP negative patients,with statistically significant differences(P<0.05).There were no statistically significant differences in gender,age,tumor size,TNM s
作者 黄慧 谭玲霞 徐诗文 陈滔 HUANG Hui;TAN Lingxia;XU Shiwen;CHEN Tao(Department of Oncology,People's Hospital of Kaizhou District,Chongqing 405400,China;Department of Orthopedics,People's Hospital of Kaizhou District,Chongqing 405400,China)
出处 《中国现代医生》 2022年第6期1-4,共4页 China Modern Doctor
关键词 异常糖链糖蛋白 CA199 早期胃癌 癌前病变 临床病理 Abnormal globular chain glycoprotein CA199 Early gastric cancer Precancerous lesions Clinicopathology
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