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曲美他嗪联合瑞舒伐他汀对冠心病心绞痛患者心功能及血液流变学的影响 被引量:1

Effects of trimetazidine combined with Rosuvastatin on cardiac function and hemorheology in patients with coronary heart disease and angina pectoris
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摘要 目的:探讨曲美他嗪联合瑞舒伐他汀对冠心病心绞痛患者心功能及血液流变学的影响。方法:选择本院2019年3月至2020年9月接收的102例冠心病心绞痛患者,并按1∶1比例随机划分成单药组、联合组。所有患者均施以常规治疗,单药组在此基础上给予瑞舒伐他汀治疗,联合组在单药组基础上加用曲美他嗪治疗,均治疗2个月。判定两组治疗结束后疗效,评价两组用药安全性,测定两组治疗前、治疗结束后血流变指标[血浆黏度、纤维蛋白原(Fib)、血小板聚集率]、心功能指标[左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDd)、左室射血分数(LVEF)]。结果:联合组治疗总有效率较单药组高(P<0.05);治疗后两组血浆黏度、Fib、血小板聚集率及LVESD、LVEDd、LVEF和同组治疗前相比均有显著改善(P<0.05),且联合组上述上述指标均显著较单药组优(P<0.05);两组不良反应发生率均较低,组间比较无统计学差异(P>0.05)。结论:对冠心病心绞痛患者实施曲美他嗪联合瑞舒伐他汀治疗,其疗效优于瑞舒伐他汀治疗,可明显改善血流变及心功能,有效控制症状,且安全性较好。
作者 王莹 Wang Ying
出处 《甘肃医药》 2022年第2期139-140,149,共3页 Gansu Medical Journal
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