摘要
促性腺激素卵泡刺激素(FSH)和黄体生成素(LH)是垂体细胞合成、分泌的多功能激素,除影响生殖系统外,还具有多重生理功能,参与老化相关疾病的发生与发展。随年龄增长,中枢神经垂体功能减退,FSH、LH合成与分泌随之发生变化,这种变化与动脉硬化性心血管疾病、代谢异常等老化相关疾病关系密切,调节FSH、LH可能成为相关疾病防治的重要环节。目前,其确切病理生理作用还不完全清楚,因此深入研究中枢神经系统功能变化与老化相关疾病的关系具有重要意义。
The gonadotrophin hormones,follicle-stimulating hormone(FSH)and luteinizing hormone(LH),are multifunctional hormones synthesized and secreted by pituitary cells.In addition to affecting the reproductive system,they also have multiple physiological functions and participate in the occurrence and development of aging-related diseases.Elevated LH and FSH levels implicated with the decline of pituitary gonadotrope cells during aging process,and recent research data indicated that these changes involve with development of many aged-related chronic diseases,such as atherosclerotic cardiovascular disease,metabolic disturbers,and others.Regulating FSH and LH may become an important link in the prevention and treatment of related diseases.At present,the underlying mechanisms for them remain elusive or largely unknown.Hence,further studies on the relation between central nerve system function and aged-related diseases are of valuable clinical significance.
作者
马晓炳
刘秀
于慧春
高健雄
崔海亮
杨春梅
孔德玉
黄军平
李贺
MA Xiao-Bing;LIU Xiu;YU Hui-Chun;GAO Jian-Xiong;CUI Hai-Liang;YANG Chun-Mei;KONG De-Yu;HUANG Jun-Ping;LI He(Department of Geriatrics, Tianjin Xiqing Hospital, Tianjin 300380, China;Characteristic Medical Center of Armed Police Force, Tianjin 300162, China;Tianjin Leczcore Hospital, Tianjin 300182, China)
出处
《中华老年多器官疾病杂志》
2022年第3期236-240,共5页
Chinese Journal of Multiple Organ Diseases in the Elderly
关键词
卵泡刺激素
黄体生成素
老化
骨质疏松
动脉硬化性心血管病
代谢异常
follicle-stimulating hormone
luteinizing hormone
ageing
osteoporosis
atherosclerotic cardiovascular disease
metabolic disturbers
