摘要
长链非编码RNA(lncRNA)是长度>200个核苷酸且不能编码蛋白的RNA。研究发现lncRNA可以调节T细胞的增殖、分化、凋亡等过程。T细胞在某些皮肤疾病的发病机制中具有重要作用,良性疾病如银屑病、特应性皮炎、白癜风和扁平苔藓,恶性疾病如蕈样肉芽肿、Sézary综合征和间变性大细胞淋巴瘤。本文就lncRNA在T细胞介导的良恶性皮肤疾病中的研究进展进行了探讨,旨在阐明lncRNA介导的发病机制,为今后的诊断和治疗指明方向。
Long non-coding RNA(lncRNA) is a kind of RNA with no protein-coding function that is longer than 200 nucleotides.Recent studies have found that lncRNA can regulate the proliferation, differentiation, apoptosis, and other processes of T cells.T cells play an important role in the pathogenesis of certain skin diseases, including benign diseases(psoriasis, atopic dermatitis, vitiligo, and lichen planus) and malignant diseases(mycosis fungoides, Sézary syndrome, and anaplastic large cell lymphoma).This article reviews the research progress of lncRNA in T cell-mediated benign and malignant skin diseases, aiming to clarify the pathogenesis mediated by LncRNA and help to define the future diagnosis and treatment.
作者
李婷婷
王艺萌
张春雷
LI Tingting;WANG Yimeng;ZHANG Chunlei(Department of Dermatology,Peking University Third Hospital,Beijing 100191,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2022年第1期10-16,共7页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金面上项目(81972560)
北京自然科学基金面上项目(7202231)
北京大学医学部青年培育项目(BMU2020PYB023)。
