摘要
目的:探讨鼻用糖皮质激素的常见不良反应,为临床合理用药提供参考。方法:回顾性分析我院2019年1月—2021年1月收治并使用鼻用糖皮质激素制剂治疗的135例变应性鼻炎患者的临床资料,按是否发生不良反应分为A组(发生不良反应)和B组(未发生不良反应),分析鼻用糖皮质激素制剂使用情况及其不良反应的影响因素。结果:鼻用糖皮质激素制剂使用最多的为布地奈德鼻喷雾剂,其次为丙酸氟替卡松鼻喷雾剂。共42例患者发生不良反应,多为轻症,主要包括鼻出血、鼻腔干燥、刺激感、咽炎、咳嗽,其中鼻腔干燥发生率最高,其次为声音嘶哑。两组性别比较,差异无统计学意义(P>0.05);两组年龄、病情严重程度、糖皮质激素使用时间、用药剂量、用药频率比较,差异有统计学意义(P<0.05);Logistic回归分析显示,年龄、病情严重程度、糖皮质激素使用时间、用药剂量、用药频率是患者发生不良反应的独立危险因素(P<0.05)。结论:年龄、病情、糖皮质激素使用时间、用药剂量、用药频率与鼻用糖皮质激素制剂不良反应的发生密切相关,临床应针对此在用药过程中进行合理干预,以减少不良反应的发生。
Objective: To investigate the common adverse reactions of nasal glucocorticoids, and to provide references for clinical rational use of drugs. Methods: The clinical data of 135 patients with allergic rhinitis treated with nasal glucocorticoids in our hospital from January 2019 to January 2021 were retrospectively analyzed. According to the occurrence of adverse reactions, they were divided into group A(adverse reactions) and group B(no adverse reactions). The use of nasal glucocorticoids and the influencing factors of adverse reactions were analyzed. Results: The most used nasal glucocorticoid preparation was budesonide nasal spray, followed by fluticasone propionate nasal spray. A total of 42 patients had adverse reactions, most of which were mild, including nose bleeding, dry nasal cavity, irritation, pharyngitis, and cough.The incidence of dryness in the nasal cavity was the highest, followed by hoarseness. There was no statistically significant difference in gender between the two groups(P >0.05);the two groups had statistically significant differences in age, severity of illness, glucocorticoid use time, dosage, and frequency of medication(P < 0.05);Logistic regression Analysis shows that age, severity of the disease, time of glucocorticoid use, dosage, and frequency of medication were independent risk factors for adverse reactions in patients(P < 0.05). Conclusion: Age, condition, glucocorticoid use time, dosage, and frequency of administration are closely related to the occurrence of adverse reactions of nasal glucocorticoid preparations. Clinical interventions should be made to reduce the occurrence of adverse reactions in the course of medication.
作者
陈海娟
侯艳鹏
CHEN Haijuan;HOU Yanpeng(Department of Otolaryngology,Shenyang Weikang Hospital,Shenyang 110000,Liaoning,China;Department of Otolaryngology,Shenyang Fourth People's Hospital,Shenyang 110000,Liaoning,China)
出处
《中国药物滥用防治杂志》
CAS
2022年第1期95-98,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
糖皮质激素
鼻用
不良反应
合理用药
Glucocorticoids
Nasal use
Adverse reactions
Rational use of drugs
