摘要
目的:探讨不同剂量阿托伐他汀钙对脑梗死患者血清胆红素的影响。方法:选取2020年1月—2021年1月中牟县人民医院收治的160例脑梗死患者作为研究对象,依据随机数表法将其分为A组、B组、C组、D组,各40例。D组采用常规治疗,A组、B组、C组分别在D组基础上采用20 mg/d、30 mg/d、40 mg/d的阿托伐他汀钙治疗,比较四组治疗有效率、血液流变学指标及血清胆红素水平,并分析阿托伐他汀钙剂量与血清胆红素的相关性。结果:A组、B组、C组总有效率均高于D组,差异有统计学意义(P<0.05);但A组、B组、C组总有效率比较,差异无统计学意义(P>0.05)。A组、B组、C组血浆黏度、全血黏度、血细胞比容改善程度均优于D组,且B组优于C组,C组优于A组,差异有统计学意义(P<0.05)。A组、B组、D组治疗前后总胆红素、直接胆红素水平比较,差异无统计学意义(P>0.05),但C组总胆红素、直接胆红素均高于A组、B组、D组,差异有统计学意义(P<0.05)。Pearson线性相关分析显示,阿托伐他汀钙剂量与血清胆红素水平呈正相关(r=0.658,P<0.05)。结论:阿托伐他汀钙治疗脑梗死相较于常规治疗有良好的疗效,且在剂量为30 mg/d时效果最为显著,在剂量为40 mg/d时可提升患者的血清胆红素水平。
Objective:To investigate the effect of different doses of atorvastatin calcium on serum bilirubin in patients with cerebral infarction.Methods:From January 2020 to January 2021,160 patients with cerebral infarction in Zhongmou County People′s Hospital were selected as the research objects.According to the random number table method,they were divided into groups A,B,C,and D,each with 40 cases.Group D received conventional treatment,groups A,B,and C were treated with atorvastatin calcium at 20 mg/d,30 mg/d,and 40 mg/d on the basis of group D,respectively.The treatment efficiency,blood rheology index and serum bilirubin level of the 4 groups were compared,and the correlation between atorvastatin calcium dose and serum bilirubin was analyzed.Results:The total effective rates of group A,group B and group C were higher than those of group D,and the difference was statistically significant(P<0.05);but there was no significant difference in the total effective rate between group A,group B and group C(P>0.05).The improvement of plasma viscosity,whole blood viscosity and hematocrit in group A,group B and group C were better than those in group D,and group B was better than group C,and group C was better than group A,the difference was statistically significant(P<0.05).There was no significant difference in the levels of total bilirubin and direct bilirubin before and after treatment in group A,group B and group D(P>0.05),but the total bilirubin and direct bilirubin in group C were higher than those in group A,group B and group D,the difference was statistically significant(P<0.05).Pearson linear correlation analysis showed that the dose of atorvastatin calcium was positively correlated with serum bilirubin level(r=0.658,P<0.05).Conclusion:Compared with conventional treatment,atorvastatin calcium has a good effect in the treatment of cerebral infarction,and the effect is most significant at a dose of 30 mg/d,and it can increase the patient’s serum bilirubin level at a dose of 40 mg/d.
作者
张丽荣
赵明枝
武俊波
朱怀宇
王丽萍
ZHANG Lirong;ZHAO Mingzhi;WU Junbo;ZHU Huaiyu;WANG Liping(The Second Department of Neurology,Zhongmou County People's Hospital,Zhengzhou 451450,Henan,China;Department of Anesthesiology,Zhongmou County People's Hospital,Zhengzhou 451450,Henan,China;Department of Neurology,Kaifeng People's Hospital,Kaifeng 475000,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2022年第1期59-62,108,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
开封市科技攻关项目(2003066)。
关键词
阿托伐他汀钙
剂量
脑梗死
血清胆红素
影响
Atorvastatin calcium
Dose
Cerebral infarction
Serum bilirubin
Influence
