摘要
肾素(原)受体(PRR)是肾素与肾素原的一种单跨膜受体。许多器官有自己的局部或组织肾素-血管紧张素系统(RAS),PRR可在RAS中发挥特异性的局部效应。肾素和肾素原可通过与PRR结合分别激活血管紧张素依赖通路和血管紧张素独立通路,从而导致一系列生理病理效应。PRR上调可促进高血压的发生以及糖尿病、肾小球损伤、肾脏疾病和炎症的进展。可溶性PRR(sPRR)是由蛋白酶切割全长PRR而产生,sPRR在各种生理病理过程中均具有关键的生物学功能,并可能成为疾病诊断的新型生物标志物,因此未来应进一步深入研究sPRR以确定其诊断价值。
(Pro)renin receptor(PRR)is a single transmembrane receptor for renin and prorenin.Many organs have their own local or tissue renin-angiotensin system(RAS),and PRR can exert specific local effects in RAS.Renin and prorenin activate angiotensin-dependent and independent pathways by binding to PRR,respectively,leading to a range of physiological and pathological effects.PRR up-regulation promotes the occurrence of hypertension and development of diabetes mellitus,glomerular injury,renal diseases and inflammation.Soluble PRR(sPRR)is generated via proteases-mediated cleavage of the full-length PRR,and plays pivotal biological functions in various physiopathological processes,and may be a novel biomarker for the diagnosis of diseases.In the future,further studies are needed to determine the diagnostic value of sPRR.
作者
薛凯
周宝龙
方辉
XUE Kai;ZHOU Baolong;FANG Hui(School of Pharmacy,Weifang Medical University,Weifang 261053,China)
出处
《医学综述》
CAS
2022年第5期865-870,共6页
Medical Recapitulate
基金
国家自然科学基金(82000400)
山东省大学生创新训练项目(S202110438054)。
