摘要
目的观察抗血管内皮生长因子(VEGF)药物治疗湿性老年性黄斑变性(wAMD)的效果及对房水和血清白细胞介素-8(IL-8)、人白血病抑制因子(LIF)、基质细胞衍生因子1-α(SDF1-α)、VEGF水平的影响。方法选取2016年5月—2020年8月90例(108眼)wAMD为研究对象,其中68例(81眼)行玻璃体腔注射Ranibizumab治疗设为观察组,22例(27眼)行保守治疗设为保守组,并以拟行白内障手术20例(20眼)设为对照组。检测并比较wAMD患者治疗前后以及对照组术前房水和血清IL-8、LIF、SDF1-α、VEGF水平。检测并比较wAMD患者治疗前后眼压值、最佳矫正视力及黄斑中心凹视网膜厚度(CRT)。结果观察组与保守组治疗前后眼压值比较差异无统计学意义(P>0.05);观察组治疗后最佳矫正视力优于治疗前及保守组,黄斑CRT小于治疗前及保守组(P<0.05)。观察组治疗前房水和血清IL-8、LIF、SDF1-α、VEGF-A、VEGF-D水平高于对照组(P<0.05);多因素Logistic回归分析显示,治疗前房水和血清IL-8、LIF、SDF1-α、VEGF-A、VEGF-D水平与wAMD的发生具有显著相关性(P<0.05,P<0.01)。观察组治疗后房水和血清IL-8、LIF、SDF1-α、VEGF-A、VEGF-D水平较治疗前降低(P<0.05)。结论玻璃体腔注射Ranibizumab治疗wAMD效果显著,可能与其能有效降低患者房水和血清IL-8、LIF、SDF1-α、VEGF-A、VEGF-D水平有关。
Objective To observe clinical efficacy of anti-vascular endothelial growth factor(VEGF)drugs in treatment of elderly patients with wet age-related macular degeneration(wAMD)and their effects on levels of interleukin-8(IL-8),human leukemia inhibitory factor(LIF),stromal cell-derived factor 1-α(SDF1-α)and VEGF in aqueous humor and serum.Methods A total of 90 patients(108 eyes)with wAMD between May 2016 to August 2020 were selected as research subjects.Among them,68 patients(81 eyes)that had undergone intravitreal injection of Ranibizumab were enrolled as observation group,and 22 patients(27 eyes)that had undergone conservative treatment were set as conservative group.Another 20 patients(20 eyes)who had planned for cataract surgery were selected as control group.Levels of IL-8,LIF,SDF1-α and VEGF in aqueous humor and serum of wAMD patients before and after treatment and those in control group before treatment were detected and compared.Values of intraocular pressure(IOP),best corrected visual acuity(BCVA)and macula lutea central retinal thickness(CRT)of wAMD patients before and after treatment were detected and compared.Results There was no significant difference in IOP before and after treatment between observation group and conservative group(P>0.05).In observation group,BCVA after treatment was better than that before treatment in same group and that in conservative group,and macula lutea CRT was lower than that before treatment in same group and that in conservative group(P<0.05).Before treatment,levels of IL-8,LIF,SDF1-α,VEGF-A and VEGF-D in aqueous humor and serum in observation group were higher than those in control group(P<0.05).Multivariate Logistic regression analysis showed that levels of IL-8,LIF,SDF1-α,VEGF-A and VEGF-D in aqueous humor and serum before treatment were significantly correlated with the occurrence of wAMD(P<0.05,P<0.01).After treatment,levels of IL-8,LIF,SDF1-α,VEGF-A and VEGF-D in aqueous humor and serum were lower than those before treatment in observation group(P<0.05).Conclusio
作者
岳春艳
刘云
丁巧娟
赵杰琼
雷晓琴
YUE Chun-yan;LIU Yun;DING Qiao-juan;ZHAO Jie-qiong;LEI Xiao-qin(Department of Ophthalmology,People's Hospital of Yanliang District,Xi'an 710089,China;Department of Ophthalmology,Shaanxi Eye Hospital the Fourth Hospital of Xi'an City,Xi'an 710004,China)
出处
《临床误诊误治》
CAS
2022年第4期40-45,共6页
Clinical Misdiagnosis & Mistherapy
基金
陕西省自然科学基础研究计划面上项目(2019JM8417)。
