摘要
Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characterize proteomic dynamics associated with CRC development and progres-sion,and identify novel therapeutic targets for intercepting the underlying oncogenic processes.We have optimized pressure cycling technology(PCT)coupled with data-independent acquisition mass spectrometry(DIA-MS)for robust and reproducible proteomic analysis of biopsy-level formalin-fixed paraffin-embedded(FFPE)tissues[3].
基金
supported by the National Key Research and Development Program of China(Grant No.2017YFC0908200),National Natural Science Founda-tion of China(Grant No.81972270,81972492,32027801,21904107),the Zhejiang Provincial Science Foundation for Distinguished Young Scholars(Grant No.LR19C050001),Hangzhou Agriculture and Society Advancement Program(Grant No.20190101A04)and 2019 Zhejiang University Academic Award for Outstanding Doctoral Candidates to YK.S(Grant No.2019071).
