摘要
目的观察氯吡格雷联合阿司匹林治疗缺血性脑血管病(ICVD)的疗效及对血浆P-选择素的影响。方法选取2018年1月—2019年1月广东省深圳市福永人民医院收治的ICVD患者69例,采用随机数字表法分为观察组35例和对照组34例。对照组采用阿司匹林治疗,观察组在对照组的基础上加用氯吡格雷治疗,2组均治疗10周。比较2组患者的临床疗效、治疗前后神经功能缺损(NDS)评分和血浆P-选择素水平。结果治疗10周后,观察组患者的总有效率为94.29%,显著高于对照组的76.47%(χ^(2)=4.417,P=0.036);2组患者NDS评分均显著低于治疗前,且观察组低于对照组(P<0.01)。治疗24 h、7 d后,2组患者的P-选择素均显著下降,且观察组低于对照组(P<0.05)。结论氯吡格雷联合阿司匹林治疗ICVD的疗效明确,可改善患者器官功能,血浆P-选择素在判断病情转归上具有良好价值,值得参考。
Objective To observe the effect of clopidogrel combined with aspirin in the treatment of ischemic cerebrovascular disease(ICVD)and its influence of plasma P-selectin.Methods A total of 69 ICVD patients admitted to Shenzhen Fuyong People’s Hospital from January 2018 to January 2019 were selected and divided into observation group 35 cases and control group 34 cases by random number table method.The control group was treated with aspirin,and the observation group was treated with clopidogrel on the basis of the control group,both groups were treated for 10 weeks.The clinical efficacy,neurological deficit(NDS)score and plasma P-selectin level were compared between 2 groups.Results After 10 weeks of treatment,the total effective rate of observation group was 94.29%,significantly higher than 76.47% of control group(χ^(2)=4.417,P=0.036).After 10 weeks of treatment,NDS scores in 2 groups were significantly lower than before treatment,and the observation group was lower than the control group(P<0.01).After 24 h and 7 d of treatment,P-selectin levels in2 groups were significantly decreased,and the observation group was lower than the control group(P<0.05).Conclusion Clopidogrel combined with aspirin in the treatment of ICVD has a clear curative effect and can improve the organ function of patients,the plasma P-selectin has a good value in judging the outcome of disease,which is worth reference.
作者
徐玮
XU Wei(Department of Neurology,Shenzhen Fuyong People's Hospital,Guangdong Province,Shenzhen 518013,China)
出处
《临床合理用药杂志》
2022年第7期8-10,共3页
Chinese Journal of Clinical Rational Drug Use
