摘要
目的系统评价醒脑静注射液联合阿替普酶治疗缺血性脑卒中的疗效和安全性。方法计算机检索中国知网、万方、VIP、CBM、PubMed、The Cochrane Library、Embase,系统收集有关醒脑静注射液联合阿替普酶治疗缺血性脑卒中的随机对照研究,纳入9项研究涉及1 005例患者,并采用RevMan 5.3软件对纳入的相关研究进行Meta分析。结果与对照组相比,观察组的有效率增加;NIHSS评分、NDS评分、缺血面积、TNF-α、PS、hs-CRP、IL-1、IL-6、IL-8水平降低;MoCA评分、ADL评分以及基底动脉、大脑中动脉左侧、大脑中动脉右侧、大脑前动脉左侧、大脑前动脉右侧、大脑后动脉左侧、大脑后动脉右侧、椎动脉左侧和椎动脉右侧血流速度升高;且两组不良反应发生率无显著差异。结论当前证据显示,醒脑静注射液联合阿替普酶对缺血性脑卒中患者有较好的疗效和安全性,但受纳入研究的质量和数量限制,所得结论仍需高质量的多中心、双盲临床随机对照试验予以验证。
Objective To systematically evaluate the efficacy and safety of xingnaojing injection combined with alteplase for ischemic stroke. Methods By searching CNKI,Wanfang,VIP,CBM,PubMed,The Cochrane Library,Embase,randomized controlled studies on xingnaojing injection combined with alteplase for ischemic stroke were systematically collected.A total of 9 studies were included,involving 1005 patients. Meta-analysis of the included related studies was performed by using RevMan 5.3 software. Results Meta-analysis showed that the effective rate of the observation group was higher than that of the control group after treatment. NIHSS degree,NDS degree,Ischemic area,TNF-α,PS,IL-8,hs-CRP,IL-1 and IL-6 were lower than those of the control group. MoCA score and ADL score were higher than those of the control group. Meanwhile,the blood flow velocity in basilar artery,middle cerebral artery,anterior cerebral artery,posterior cerebral artery and vertebral artery were higher than those of the control group. Adverse event incidence was not statistically different between the two groups. Conclusion The current evidence showedxingnaojing injection combined with alteplase had better curative effect and safety in patients with cerebral infarction. However,the obtained conclusions needed to be validated by high-quality multi-center,double-blind clinical randomized controlled trials,due to the limited quality and quantity of the included studies.
作者
郭飞
黄云慧
黄宇靖
牛慧芳
杜爱玲
GUO Fei;HUANG Yunhui;HUANG Yujing;NIU Huifang;DU Ailing(The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2022年第2期206-211,共6页
The Journal of Practical Medicine
基金
河南省医学科技攻关计划项目(编号:2018020372)。
