摘要
目的探究中药干预对脑内微小病变血管性危险因子及脑梗死发病率的影响。方法纳入2020年1月至2021年8月淮滨县中医院脑病科接收的89例脑内微小病变患者进行研究,根据随机排列法进行分组,包括常规组44例,予常规药物干预(阿司匹林);试验组45例,予中药干预(桂枝茯苓丸加地龙),观察两组干预前(首次就诊时)、干预后(干预6个月后)血管性危险因子(血压、血脂、血糖)变化及治疗期间脑梗死发病率的差异。结果试验组干预前、后的舒张压、空腹血糖水平与常规组比较均差异无统计学意义(P>0.05);试验组干预后的收缩压低于干预前,比较差异有统计学意义(P<0.05),但与同时期的常规组比较差异无统计学意义(P>0.05);试验组干预后的总胆固醇水平低于干预前,且低于同时期的常规组,比较差异有统计学意义(P<0.05),但常规组干预后与干预前比较差异无统计学意义(P>0.05);随访6个月,试验组脑梗死发病率为4.44%,与常规组的9.09%比较差异无统计学意义(P>0.05)。结论中药干预可有效控制血管性危险因子的影响,对脑梗死的预防起到一定的积极作用,可用于脑内微小病变的治疗。
Objective To explore the effect of Chinese herbal medicine intervention on vascular risk factors and incidence of cerebral infarction.Methods A total of 89 patients with minimal changes in the brain were enrolled from January 2020 to August 2021 in the department of neurology,Huaibin County Hospital of Traditional Chinese medicine,according to the method of random arrangement,44 cases were divided into the routine group and the experimental group,45 cases were treated with traditional Chinese medicine(Guizhi Fuling pill plus earthworm),the changes of vascular risk factors(blood pressure,blood lipid,blood glucose)and the incidence of cerebral infarction were observed before(first visit)and after(6 months after intervention)intervention.Results There was no significant difference in diastolic pressure and fasting blood glucose before and after intervention in the experimental group(P>0.05).The systolic pressure of the experimental group after intervention was lower than that before intervention(P<0.05),but there was no significant difference compared with the control group(P>0.05).The total cholesterol level of the experimental group after intervention was lower than that before intervention and lower than that of the routine group at the same time(P<0.05),but there was no statistical difference between the routine group after intervention and before intervention(P>0.05).After 6 months follow-up,the incidence of cerebral infarction in the experimental group was 4.44%,there was no significant difference compared with 9.09% in the routine group(P>0.05).Conclusion Chinese herbal medicine intervention can effectively control the influence of vascular risk factors,play a positive role in the prevention of cerebral infarction,can be used for the treatment of small lesions in the brain.
作者
王振永
丁泽昌
李婷
WANG Zhenyong;DING Zechang;LI Ting(Department of Neurology,Huaibin County Hospital of traditional Chinese medicine,Xinyang Henan 464000,China)
出处
《临床研究》
2022年第1期96-99,共4页
Clinical Research
关键词
血管性危险因子
脑内微小病变
中药干预
脑梗死
vascular risk factors
small brain lesions
traditional Chinese medicine intervention
cerebral infarction
