摘要
经颅磁刺激是一种广泛应用于神经精神类疾病诊断与治疗的无创神经刺激技术,影像引导经颅磁刺激导航能够保证刺激线圈的准确定位。然而,临床禁忌症会使患者的个体影像难以获得,导致无法实现影像引导。为解决该问题,提出构建一种个性化近似影像,以替代个体影像用于导航。首先利用导航系统定位装置获取患者头皮轮廓点,并基于泊松重建算法重建头皮,接着结合控制点自动定位方法获取头皮控制点,最终利用薄板样条插值算法实现标准模板的非刚性变形,从而构建个性化模型。对个性化模型的头皮、脑表面和脑靶点的精度进行验证,结果表明:构建的真人个性化模型的头皮精度可达到(2.8±0.5)mm,脑表面精度可达到(3.1±0.6)mm。手部肌肉对应脑部靶点精度可达到(9.2±4.1)mm,满足经颅磁刺激导航用于神经系统疾病诊断中的多靶点定位需求;背外侧前额叶靶点精度可达到(8.9±5.1)mm,优于临床常用替代靶点脑电电极F3的精度(16.1±5.0)mm,能够满足经颅磁刺激导航用于精神类疾病治疗中靶点准确重复定位需求。
Transcranial magnetic stimulation is a non-invasive stimulation technique widely used in the diagnosis and treatment of neurological and psychiatric diseases.Image-guided transcranial magnetic stimulation navigation can ensure the accurate positioning of the stimulation coil.However,some clinical contraindications make it difficult to obtain individual medical images of some patients,leading to the failure of image guidance.To solve this problem,this paper proposed to construct individualized images to replace individual images for navigation.First,we used positioning devices to acquire the patient′s scalp contour points;and reconstructed the scalp surface based on Poisson reconstruction algorithm;then combined the automatic control points positioning method to locate control points;finally used the thin plate spline interpolation algorithm to construct individualized model.We tested the accuracy of the scalp,brain surface and brain targets of the individualized models.The results showed that the scalp accuracy reached(2.8±0.5)mm,and the brain surface accuracy reached(3.1±0.6)mm.The accuracy of the hand motor cortex target reached(9.2±4.1)mm,which met the needs of multi-target localization in the diagnosis of neurological diseases by transcranial magnetic stimulation navigation.The accuracy of the dorsolateral prefrontal lobe target reached(8.9±5.1)mm,which is better than the commonly used clinical alternative target(EEG electrode F3)whose accuracy is(16.1±5.0)mm.In conclusion,the accuracy can meet the need of repeated target localization in transcranial magnetic stimulation navigation for the treatment of mental diseases.
作者
张芸
丁辉
王广志
Zhang Yun;Ding Hui;Wang Guangzhi(Department of Biomedical Engineering,Tsinghua University,Beijing 100084,China)
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2022年第1期1-9,共9页
Chinese Journal of Biomedical Engineering
基金
清华大学自主科研计划(20197010009)
国家自然科学基金(U20A20389)。
关键词
经颅磁刺激
影像导航
个性化模板影像
立体定向
多靶点定位
transcranial magnetic navigation
image guided navigation
individualized template image
stereotactic
multi-target localization
