摘要
目的:探讨穴位贴敷辅助五味消毒饮对类风湿性关节炎(RA)患者免疫功能、Th17/Tregs平衡的影响。方法:选取2019年10月至2020年10月该院收治的RA患者158例,采用完全随机法分为对照组、观察组,每组79例。对照组患者使用五味消毒饮治疗,观察组患者使用穴位贴敷联合五味消毒饮治疗。对两组患者的中医证候、关节功能恢复情况进行评价;采用魏氏法检测红细胞沉降率(ESR),酶标分析仪检测类风湿因子(RF)、白细胞介素(IL)1β和IL-3水平,免疫透射比浊法检测脂质过氧化物(LPO)、总抗氧化能力(TAOC)水平,流式细胞仪检测T淋巴细胞亚群、Th17/Tregs水平;对比两组患者的治疗效果。结果:治疗后,观察组患者中医证候评分、关节肿痛评分和活动评分明显低于对照组,晨僵时间明显短于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者RF、ESR、LPO、TAOC、IL-1β和IL-3水平明显低于对照组,CD8^(+)、Th17/Tregs水平明显低于对照组,CD4^(+)水平明显高于对照组,差异均有统计学意义(P<0.05)。观察组患者的总有效率为92.41%(73/79),明显高于对照组的81.01%(64/79),差异有统计学意义(P<0.05)。结论:使用穴位贴敷辅助五味消毒饮治疗RA,能够减轻患者的中医证候,促进关节功能恢复,调控ESR、RF水平,减轻炎症反应、氧化应激反应的严重程度,调节Th17/Tregs平衡,改善患者的免疫功能,治疗效果显著。
OBJECTIVE:To probe into the effects of acupoint application combined with Wuwei Xiaodu decoction on immune function and Th17/Tregs balance in patients with rheumatoid arthritis(RA).METHODS:Totally 158 patients with RA admitted into the hospital from Oct.2019 to Oct.2020 were extracted to be divided into the control group and the observation group via the completely random method,with 79 cases in each group.The control group was given Wuwei Xiaodu decoction,while the observation group received acupoint application combined with Wuwei Xiaodu decoction.Traditional Chinese medicine syndrome and joint function recovery of two groups were evaluated.The level of erythrocyte sedimentation rate(ESR)was detected by Westergren method,the levels of rheumatoid factor(RF),interleukin(IL)-1β and IL-3 were detected by enzyme plate analyzer,and levels of lipid peroxide(LPO)and total antioxidant capacity(TAOC)were detected by immunotransmission turbidimetry,levels of T lymphocyte subsets and Th17/Tregs were detected by flow cytometry.The therapeutic effects of two groups were compared.RESULTS:After treatment,the traditional Chinese medicine syndrome score,joint swelling and pain score,activity score of the observation group were significantly lower than those of the control group,and the morning stiffness time was significantly shorter than that of the control group,with statistically significant differences(P<0.05).After treatment,the levels of RF,ESR,LPO,TAOC,IL-1β and IL-3 in the observation group were significantly lower than those in the control group,the levels of CD8^(+) and Th17/Tregs were significantly lower than those in the control group,while the levels of CD4^(+) were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was 92.41%(73/79),significantly higher than 81.01%(64/79)of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:The efficacy of acupoint application combined with Wuwe
作者
孙思东
边祥涛
SUN Sidong;BIAN Xiangtao(Dept.of Orthopaedics,the Second Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,China)
出处
《中国医院用药评价与分析》
2022年第3期293-296,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
辽宁省科学技术计划项目(No.2018020130-323)。
关键词
类风湿性关节炎
穴位贴敷
五味消毒饮
免疫功能
炎症反应
Rheumatoid arthritis
Acupoint application
Wuwei Xiaodu decoction
Immune function
Inflammatory response
