摘要
目的观察柴芩石膏汤治疗病毒性感冒的临床疗效及其对炎症因子的影响。方法将100例诊断为病毒性感冒的患者随机分为对照组和治疗组,每组各50例。治疗组予以柴芩石膏汤1剂/d,分2次口服,对照组予以磷酸奥司他韦胶囊75 mg,日1次口服。疗程5 d。治疗前后对两组患者中医证候进行评分,并判定疗效;记录患者退热时间;在治疗后第3、5天分别统计各项临床症状的缓解率;采用ELASA法检测治疗前后患者血清中白介素1(IL-1)、肿瘤坏死因子(TNF-α)、C-反应蛋白(CPR)的含量。结果 (1)治疗组体温首次下降低于37.5℃及体温下降后24 h不反弹的时间均低于对照组,两组之间差异有统计学意义(P<0.05)。(2)治疗后两组患者的中医证候评分均显著下降,治疗组低于对照组,两组之间的差异有统计学意义(P<0.05)。(3)治疗组总有效率为91.6%,对照组的总有效率为86.7%,两组之间差异有统计学意义(P<0.05)。(4)治疗后第3天治疗组与对照组在咳嗽、鼻塞、流涕症状完全缓解率差异无统计学意义(P>0.05),而在咽痛、肌肉酸痛、乏力方面差异显著,治疗组的缓解率高于对照组(P<0.05);第5天两组患者在咳嗽、肌肉酸痛、乏力方面差异显著,治疗组的缓解率高于对照组(P<0.05),其它症状缓解率差异无统计学意义(P>0.05)。(5)治疗后两组患者的IL-1、TNF-α、CPR含量均显著下降,治疗组显著低于对照组,两组之间差异有统计学意义(P<0.05)。结论柴芩石膏汤通过抑制炎症因子IL-1、TNF-α减轻病毒引起的炎症反应治疗流感,临床疗效显著。
Objective To observe the clinical effect of Chaiqin Shigao Decoction(柴芩石膏汤)on influenza and its effect on inflammatory factors.Methods A total of 100 patients diagnosed with influenza were randomly divided into control group and treatment group with 50 cases in each group.In the treatment group,1 dose of Chaiqin Shigao Decoction was administered orally twice a day.The control group was given oseltamivir phosphate capsule 75 mg once a day orally,treatment for five days.The TCM syndromes of the two groups were scored before and after treatment,and the curative effect was determined.The patients’antifebrile time was recorded.The remission rate of each clinical symptom was calculated on the 3 th and 5 th day after treatment.ELASA method was used to detect the level of IL-1,TNF-αCPR in serum of patients before and after treatment.Results(1)The first hypothermia of the treatment group was lower than that of the control group,and the time of no rebound 24 h after hypothermia was lower than that of the control group,with significant differences between the two groups(P<0.05).(2)After treatment,TCM syndrome scores of patients in both groups were significantly decreased,and those in the treatment group were lower than those in the control group,with statistically significant differences between the two groups(P<0.05).(3)The total effective rate was 91.6%in the treatment group and 86.7%in the control group,the difference between the two groups was statistically significant(P<0.05).(4)There was no significant difference in the rate of complete relief of cough,nasal congestion and runny nose between the treatment group and the control group on day 3 after treatment(P>0.05),and there was significant difference in pharyngeal pain muscle soreness and fatigue,and the remission rate in the treatment group was higher than that in the control group(P<0.05);On day 5,there was a significant difference in cough muscle soreness and fatigue between the two groups,and the remission rate in the treatment group was higher than
作者
李雨鹏
宓丹
潘冲
李晓梅
LI Yupeng;MI Dan;PAN Chong;LI Xiaomei(The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China)
出处
《辽宁中医药大学学报》
CAS
2022年第2期103-107,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
辽宁省科技厅项目(2015225015,2019-ZD-0841)
国家区域中医诊疗中心(肺病)建设项目。
