摘要
目的:探讨血清淀粉样蛋白A(SAA)、D-二聚体(D-D)、肌酸激酶同工酶(CK-MB)联合检测对川崎病患儿冠状动脉损伤(CAL)的诊断价值。方法:选取2018年9月~2021年5月我院收治的80例川崎病患儿,根据是否合并CAL分为CAL组(n=34)和NCAL组(n=46)。收集患儿基础资料,并检测SAA、D-D、CK-MB水平。多因素Logistic回归分析川崎病患儿CAL影响因素,受试者工作特征(ROC)曲线分析血清SAA、D-D、CK-MB水平对川崎病患儿CAL的诊断价值。结果:与NCAL组比较,CAL组C反应蛋白(CRP)、红细胞沉降率(ESR)、SAA、D-D、CK-MB水平升高(P<0.05)。多因素Logistic回归分析显示,CRP、ESR、SAA、D-D、CK-MB为川崎病患儿CAL独立影响因素(P<0.05)。SAA、D-D、CK-MB、三项联合诊断川崎病患儿CAL的曲线下面积(AUC)分别为0.661、0.687、0.746、0.799,联合应用的诊断效能最高。结论:血清SAA、D-D、CK-MB是川崎病患儿CAL独立影响因素,且联合检测以上指标可辅助诊断川崎病患儿CAL。
Objective: To investigate the diagnostic value of the combined detection of serum amyloid A(SAA), D-dimer(D-D)and creatine kinase MB(CK-MB) in the coronary artery lesions(CAL) in children with Kawasaki disease. Methods: 80 children with Kawasaki disease who were admitted to our hospital from September 2018 to May 2021 were selected, and they were divided into CAL group(n=34) and NCAL group(n=46) according to whether they were combined with CAL. Basic information was collected from the children, and SAA, D-D and CK-MB levels were measured. Multivariate Logistic regression analysis was used to analyze the influencing factors of CAL in children with Kawasaki disease. Receiver operating characteristic(ROC) curve was used to analyze the diagnostic value of serum SAA, D-D and CK-MB levels of CAL in children with Kawasaki disease. Results: Compared with NCAL group, the C-reactive protein(CRP), erythrocyte sedimentation rate(ESR) SAA, D-D and CK-MB levels in CAL group increased(P<0.05).Multivariate Logistic regression analysis showed that CRP, ESR, SAA, D-D and CK-MB were independent influencing factors of CAL in children with Kawasaki disease(P<0.05). The area under the curve(AUC) of CAL in children with Kawasaki disease diagnosed by SAA,D-D, CK-MB and three items were 0.661, 0.687, 0.746 and 0.799 respectively, the diagnostic efficiency of combined application was the highest. Conclusion: Serum SAA, D-D and CK-MB are independent influencing factors of CAL in children with Kawasaki disease, and combined detection of these indicators can assist in the diagnosis of CAL in children with Kawasaki disease.
作者
卢松建
靳晶晶
董坤
朱启东
王凤晨
LU Song-jian;JIN Jing-jing;DONG Kun;ZHU Qi-dong;WANG Feng-chen(Emergency Internal Medicine,Anhui Provincial Children's Hospital,Hefei,Anhui,230000,China)
出处
《现代生物医学进展》
CAS
2022年第4期757-760,共4页
Progress in Modern Biomedicine
基金
安徽省科技攻关自筹计划项目(1604a08020102)。
