摘要
目的:探讨置管后7d内启动腹膜透析(PD)的安全性及预后。方法:本研究回顾性分析了四川省人民医院PD中心2008-01-01~2016-12-31的腹膜置管后早期启动PD患者的并发症及导管存活情况,随访3年。根据置管后开始PD时间将患者分为三组,P1组(≤7d)、P2组(8~13d)、P3组(≥14d)。所有患者均使用相同的PD起始剂量。研究的主要终点为导管技术失败,次要终点包括与PD相关的并发症及死亡。结果:本研究纳入437例患者,其中P1组163例、P2组189例、P3组85例。三组的1年和3年技术存活率分别为95.7%、92.6%、87.1%和94.5%、89.9%、85.9%(P=0.066)。三组的1年和3年患者生存率分别为90.2%、94.2%、97.6%和81.0%、82.5%、85.9%(P=0.595)。三组间围手术期并发症、感染并发症、导管通畅率、导管移位率无统计学差异。结论:置管术后7 d内启动PD患者与延迟开始透析者的导管技术存活率、患者生存率及PD相关并发症均无统计学差异,提示在置管后7 d内启动PD可作为常规治疗方式。
Objective:This study observed the safety and prognosis of early initiation(7 days)of peritoneal dialysis(PD)after catheterization.Methodology:This study retrospectively analyzed the complications and catheter survival of patients who underwent PD early after peritoneal catheterization in our center from January 1,2008 to December 31,2016.The average follow-up time was 3 years.According to the time of started PD after catheterization,the patients were divided into three groups:P1(≤7 days),P2(8~13 days)and P3(≥14 days).All patients used the same starting dose of PD.The primary end point of study was catheter technical failure,the secondary end points included PD related complications and death.Results:437 patients were included,including 163 cases in P1 group,189 cases in P2 group and 85 cases in P3 group.The 1-year and 3-year technical survival rates in P1,P2 and P3 groups were 95.7%,92.6%and 87.1%;94.5%,89.9%and 85.9%,respectively(P=0.066).The 1-year and 3-year patient survival were 90.2%、94.2%、97.6%and 81.0%、82.5%、85.9%,respectively(P=0.595).There were no significant differences in perioperative complications,infective complications or catheter displacement rates among the three groups.Conclusion:Patients initialed PD within 7 days after catheterization were similar to patients with delayed dialysis initiation in technique survival,patient survival and PD related complications.
作者
陈艺方
陈秀玲
高辉
王君如
尹丽娟
周勤
李怡
李贵森
陈瑾
CHEN Yifang;CHEN Xiuling;GAO Hui;WANG Junru;YIN Lijuan;ZHOU Qin;LI Yi;LI Guisen;CHEN Jin(Southwest Medical University,Luzhou 646000,China;Sichuan Provincial Building Hospital,Chengdu 610000,China;Sichuan Provincial People's Hospital,Chengdu 610000,China)
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2022年第1期33-38,共6页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
四川省科技厅课题(2017YSKY0001)
四川省重点研发项目(2019YFS0538)
四川省肾脏病临床研究中心项目(2019YFS0538)。
关键词
终末期肾病
腹膜透析
早期腹膜透析
技术存活率
end stage renal disease
peritoneal dialysis
early-start dialysis
technique survival
