摘要
目的:探讨妊娠晚期阴道微生态失调对早产的预测价值。方法:回顾性分析2019年6月-2020年11月在深圳市罗湖区妇幼保健院收治的100例孕妇的临床资料。根据怀孕周期,≥37周有分娩指征的孕妇为足月组(60例),孕周为28~36周有早产迹象的孕妇为早产组(40例)。所有孕妇均接受阴道微生态检查,分析其阴道微生态环境变化。比较两组密集度及菌群多样性,细菌性阴道病(BV)及需氧菌阴道炎(AV)发生率,微生物酶类指标及过氧化氢(H_(2)O_(2))、pH,采用ROC分析H_(2)O_(2)、pH及联合检测对早产的预测价值。结果:足月组密集度和菌群多样性正常率分别为96.67%、95.00%,均显著高于早产组的32.50%、40.00%(P<0.05)。足月组BV和AV的发生率分别为1.67%和1.67%,均显著低于早产组的60.00%和30.00%(P<0.05)。足月组H_(2)O_(2)值和白细胞酯酶(LE)、阳性率均显著高于早产组,唾液酸苷酶(NA)阳性率和pH值均显著低于早产组(P<0.05)。ROC结果显示,H_(2)O_(2)、pH及其联合检测预测早产的AUC分别为0.645、0.799和0.828(P<0.05)。结论:妊娠晚期阴道微生态失调与早产具有相关性,阴道炎症疾病和微生态环境的变化会引起早产的发生。
Objective:To explore predictive value of vaginal microecology disorders in late pregnancy for preterm delivery.Method:The clinical data of 100 pregnant women admitted to Shenzhen Luohu Maternal and Child Health Hospital from June 2019 to November 2020 were retrospectively analyzed.According to the pregnancy cycle,pregnant women with indications of delivery and≥37 weeks was the full-term group(60 cases),and pregnant women with signs of preterm delivery between 28 and 36 weeks was the preterm group(40 cases).All pregnant women received vaginal microecological examination to analyze the changes of vaginal microecological environment.The density and diversity of bacterial communities,incidence of bacterial vaginosis(BV)and aerobic bacterial vaginitis(AV),microbial enzymes indexes,hydrogen peroxide(H_(2)O_(2))and pH were compared between the two groups.ROC was used to analyze the predictive value of H_(2)O_(2),pH and combined detection for premature delivery.Result:The normal rates of density and diversity of bacterial communities in full-term group were 96.67%and 95.00%respectively,which were significantly higher than 32.50%and 40.00%in preterm group(P<0.05).The incidence of BV and AV in full-term group was 1.67%and 1.67%respectively,which were significantly lower than 60.00%and 30.00%in preterm group(P<0.05).H_(2)O_(2)value,and leucocyte esterase(LE)positive rate in full-term group were significantly higher than those in preterm group,while neuraminidase(NA)positive rate and pH value in full-term group were significantly lower than those in preterm group(P<0.05).ROC results showed that the AUC of H_(2)O_(2),pH and their combined detection in the forecast of premature delivery were 0.645,0.799 and 0.828 respectively(P<0.05).Conclusion:Vaginal microecological disorders in late pregnancy is associated with preterm delivery.Vaginal inflammatory diseases and changes in microecological environment will cause preterm delivery.
作者
赖建芬
熊莉芳
张哲
LAI Jianfen;XIONG Lifang;ZHANG Zhe(不详;Shenzhen Luohu Maternal and Child Health Hospital,Shenzhen 518000,China)
出处
《中外医学研究》
2022年第7期75-78,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
妊娠晚期
阴道微生态失调
早产
Late pregnancy
Vaginal microecological disorder
Preterm birth
