摘要
目的探讨双相情感障碍抑郁发作患者血清尿酸、同型半胱氨酸与认知功能的相关性。方法将25例双相情感障碍抑郁发作患者设为研究组,25名健康志愿者设为对照组。比较两组血清尿酸、同型半胱氨酸水平及简易精神状态检查量表、汉密顿抑郁量表评分,分析研究组血清尿酸、同型半胱氨酸水平及简易精神状态检查量表、汉密顿抑郁量表评分相关性。结果研究组血清尿酸、同型半胱氨酸水平及汉密顿抑郁量表评分显著高于对照组(P<0.01),简易精神状态检查量表评分显著低于对照组(P<0.01)。研究组简易精神状态检查量表评分与汉密顿抑郁量表评分呈显著正相关(P<0.05),与血清尿酸、同型半胱氨酸水平无显著相关性(P>0.05)。结论双相情感障碍抑郁发作患者存在认知功能障碍,血清尿酸、同型半胱氨酸水平与双相情感障碍抑郁发作患者认知功能无显著相关性。
Objective To investigate the correlation between serum uric acid(UA),homocysteine(Hcy)and cognitive function in patients with depressive episode of bipolar disorder.Methods Twenty-five patients with depressive episode of bipolar disorder were set as the study group,and 25 healthy volunteers were set as the control group.The levels of serum,the scores of mini-mental state examination(MMSE)and Hamilton depression scale(HAMD) were compared between the two groups.The correlation between the levels of UA,Hcy and the scores of MMSE and HAMD was analyzed.Results The levels of serum UA,Hcy and HAMD in the study group were significantly higher than those in the control group(P<0.01),and the MMSE score was significantly lower than that in the control group(P<0.01).There was a significant positive correlation between MMSE score and HAMD score in the study group(P<0.05),but there was no significant correlation with serum UA and Hcy levels(P>0.05).Conclusions Patients with depressive episode of bipolar disorder have cognitive impairment,and serum UA and Hcy levels are not significantly correlated with cognitive function in patients with depressive episode of bipolar disorder.
作者
杜育如
张理强
谢滨浩
黄志敏
Du Yuru;Zhang Liqiang;Xie Binhao;Huang Zhimin(The Third People's Hospital of Zhanjiang City,Zhanjiang 524000,Guangdong,China)
出处
《临床心身疾病杂志》
CAS
2022年第1期24-27,共4页
Journal of Clinical Psychosomatic Diseases
