摘要
目的:探讨抑郁症患者血清维生素D水平及其与抑郁症病情的相关性。方法:随机抽取门诊抑郁症患者80例(抑郁症组),以电发光化学法测定血清25(OH)D3;并与50名性别、年龄相匹配的体检者(对照组)比较;采用汉密尔顿抑郁量表(HAMD)24项对抑郁症患者进行评估,分析血清25(OH)D3水平与HAMD评分的关系。结果:抑郁症组血清25(OH)D3[(25.54±7.09)ng/ml]明显低于对照组[(42.03±10.21)ng/ml](P<0.01);抑郁症组血清维生素D不足率(60%)或缺乏率(25%)明显高于对照组(8%,0)(P均<0.01);抑郁症患者血清25(OH)D3水平与HAMD评分呈负相关(r=-0.73,P<0.01)结论:抑郁症患者血清维生素D水平降低,并与其病情相关。
To explore the serum vitamin D level and its correlation with the degree of depres-sion in patients with major depression（MD）. Method：The serum vitamin D level was detected by electric light chemical method in 80 MD outpatients selected randomly（MD group）,the result was compared with 50 gender,age-matched normal controls（control group）. The MD patients was assessed by 24-item Hamilton de-pression rating scale（HAMD）,and the correlation between the serum vitamin D level and HAMD score were analyzed. Results：The level of serum 25（OH）D3 in MD group[（25. 54 ± 7. 09）ng/ ml]was significantly lower than controls group[（42. 03 ± 10. 21）ng/ ml]（P ﹤ 0. 01）. In MD group,the rates of less and lack of se-rum vitamin D（60± ,25± ）were significantly higher than those in the control group（8± ,0）（ all P ﹤0. 01）. There was a negative correlation between serum 25（OH）D3 and HAMD score in MD patients（ r =- 0. 73,P ﹤ 0. 01）. Conclusion：The serum vitamin D levels in MD patients is lower,and which is associat-ed with depression.
出处
《临床精神医学杂志》
2014年第4期230-231,共2页
Journal of Clinical Psychiatry
基金
上海市浦东新区科技发展基金(PKJ2013-Y44)
关键词
维生素D
抑郁症
vitamin D
major depression
