摘要
目的探讨唾液酸(SA)、C反应蛋白(CRP)对阻塞型睡眠呼吸暂停低通气综合征(OSAHS)合并2型糖尿病(T2DM)患者的影响。方法选取2019年1月-2019年8月在徐州医科大学附属淮安医院呼吸与危重症医学科住院患者75例,其中,OSAHS组45例,OSAHS合并T2DM组30例。选取同期在该院体检中心健康体检者30例为健康对照组。收集研究对象的一般资料,检测CRP、SA、纤维蛋白原(FIB)水平,采用便携式多导睡眠记录仪记录患者的呼吸暂停低通气指数(AHI)、平均血氧饱和度(MSaO_(2))、低通气指数(HI),并进行数据分析。影响因素的分析采用多元逐步线性回归或Logistic逐步回归分析。相关性分析用Spearman法。结果OSAHS组和OSAHS合并T2DM组患者CRP、SA水平高于健康对照组(P<0.05);OSAHS合并T2DM组患者CRP、SA水平高于OSAHS组(P<0.05)。OSAHS合并T2DM组和OSAHS组患者的AHI、MSaO_(2)、HI与健康对照组比较,差异有统计学意义(P<0.05),OSAHS合并T2DM组AHI、HI和MSaO_(2)与OSAHS组比较,差异有统计学意义(P<0.05)。BMI、SA和FBG为低通气的危险因素(P<0.05)。Logistic逐步回归分析显示,CRP[OR=1.258(95%CI:1.014,1.561)]、SA[OR=4.232(95%CI:1.026,17.460)]和HI[OR=1.264(95%CI:1.003,1.594)]是OSAHS患者合并T2DM的独立危险因素(P<0.05)。相关性分析发现,血清SA、CRP与AHI呈正相关(P<0.05),与FBG呈正相关(P<0.05),与MSaO_(2)呈负相关(P<0.05)。结论SA水平与OSAHS患者疾病严重程度相关,SA、CRP和HI是OSAHS患者合并2型糖尿病的独立危险因素,检测OSAHS患者的血清SA水平或许可评估患者体内的炎症状态及合并T2DM的可能风险。
Objective To investigate the changes of serum sialic acid(SA)and C-reactive protein(CRP)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)and type 2 diabetes mellitus(T2DM).Methods A total of 105 subjects were included in the study.30 health controls were set as health controls group,45 OSAHS patients were set as OSAHS group,and 30 OSAHS patients complicated with type 2 diabetes were set as OSAHS patients complicated with type 2 diabetes group.All patient were inquired general information of patients.CRP,SA,FIB,and other indicators were collected through laboratory tests,and respiratory parameters was monitored by portable sleep apnea detector.All data are analyzed finally.Results The levels of CRP and SA in OSAHS group and OSAHS combined with T2DM group were higher than those in healthy control group(P<0.05);The levels of CRP and SA in OSAHS combined with T2DM group were higher than those in OSAHS group(P<0.05).There was significant difference in AHI,MSaO_(2) and hi between OSAHS combined with T2DM group and OSAHS group and healthy control group(P<0.05).There was significant difference in AHI,hi and MSaO_(2) between OSAHS combined with T2DM group and OSAHS group(P<0.05).BMI,SA and FBG were the risk factors of hypoventilation(P<0.05).Logistic stepwise regression analysis showed that CRP[OR=1.258(95%CI:1.014,1.561)],SA[OR=4.232(95%CI:1.026,17.460)],and HI[OR=1.264(95%CI:1.003,1.594)]were independent risk factors for OSAHS patients with T2DM(P<0.05).Correlation analysis showed that serum SA and CRP were positively correlated with AHI(P<0.05),positively correlated with FBG(P<0.05),and negatively correlated with MSaO_(2)(P<0.05).Conclusions There is a correlation between the level of SA and sleep disorders in OSAHS patients.High levels of SA and CRP are risk factors for type 2 diabetes in OSAHS patients,which should be paid attention to.
作者
李影
郑玉龙
万玉峰
辜冲
Ying Li;Yu-long Zheng;Yu-fengWan;Chong Gu(Department of Respiratory and Critical Care Medicine,Huai'an Hospital Affiliated to Xuzhou Medical University,Huai'an,Jiangsu 223001,China;Department of Respiratory Medicine,Huai'an First People's Hospital,Huai'an,Jiangsu 223300,China)
出处
《中国现代医学杂志》
CAS
北大核心
2022年第5期75-79,共5页
China Journal of Modern Medicine
