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阻塞性睡眠呼吸暂停综合征致慢性缺氧性脑病一例报道

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摘要 阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)是指各种原因导致睡眠状态下反复出现呼吸暂停和(或)低通气,引起低氧血症、高碳酸血症、睡眠中断,从而使机体发生一系列病理生理改变的临床综合征[1]。随着呼吸暂停低通气指数(apnea/hypopnea index,AHI)增高,OSAHS患者认知功能受损明显,海马体积萎缩更明显,脑白质病变更加严重[2]。OSAHS患病率较高,高发于男性、高龄、有吸烟史、肥胖及颈围增粗、上气道解剖异常、肌肉松弛、有家族史的人群。虽然人们对疾病的认识逐年提高,但OSAHS的发病率远高于流行病学统计数据,且发病率逐年上升。该病临床表现多样,病情迥异,症状较轻者极易忽视而使病情加重,造成不可逆的脑缺氧性损伤。
出处 《神经损伤与功能重建》 2022年第3期182-184,共3页 Neural Injury and Functional Reconstruction
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