摘要
目的分析原发性腹膜癌(PPC)后继发第二原发恶性肿瘤(SPM)患者的流行病学及生存。方法从监测、流行病学和结果(SEER)数据库中收集1975-2016年诊断为PPC及继发SPM的患者。用Kaplan-Meier法进行生存分析。以患者死亡为竞争风险事件,使用Fine and Gray模型计算累积发病率。结果共纳入符合条件的PPC患者1494例,其中发生SPM患者59例。PPC患者的5、10及20年SPM累积发病率分别为1.6%、4.7%及6.4%。发生SPM患者中位总生存时间为79.0个月,发生SPM的中位间隔时间为38.0个月,主要部位为乳腺(27.1%)、白血病(8.5%)、肺(8.5%)和膀胱(8.5%)。发生SPM后中位生存时间为25.0个月。结论PPC后SPM患者预后较差,应针对危险因素进行干预。
Objective To analyze the epidemiology and survival of patients with secondary second primary malignancy(SPM)following primary peritoneal carcinoma(PPC).Methods Patients diagnosed with PPC and secondary SPM from 1975-2016 were collected from the Surveillance,Epidemiology and Outcomes(SEER)database.Survival analysis was performed using the Kaplan-Meier method.Cumulative incidence was calculated using the Fine and Gray model with patient death as a competing risk event.Results A total of 1494 eligible patients with PPC were included,of whom 59 had SPM.The cumulative incidence of SPM at 5,10 and 20 years in patients with PPC was 1.6%,4.7%and 6.4%,respectively.The median overall survival time for patients with SPM was 79.0 months,with a median interval of 38.0 months between occurrences,with the main sites being the breast(27.1%),leukaemia(8.5%),lung(8.5%)and bladder(8.5%).The median survival time after the occurrence of SPM was 25.0 months.Conclusion Patients with SPM after PPC have a poor prognosis and interventions should be made to address risk factors.
作者
李晓多
杨峤
张春高
孙建国
LI Xiaoduo;YANG Qiao;ZHANG Chungao;SUN Jianguo(Department of Obstetrics and Gynecology,Qijiang District Maternal and Child Health Hospital,Chongqing 401420,China;Department of Ultrasound,the 941st Hospital of the PLA Joint Logistic Support Force,Xining 810007,China;Department of General Surgery,Qijiang Hospital of Traditional Chinese Medicine,Chongqing 401420,China;Department of Oncology,the Second Affiliated Hospital of Army Medical University,Chongqing 400037,China)
出处
《重庆医学》
CAS
2022年第6期995-999,共5页
Chongqing medicine
基金
重庆市綦江区科技计划指导性项目(2020077)。
