摘要
目的分析血清糖类抗原19-9(CA19-9)、内皮细胞特异性分子1(ESM-1)及C反应蛋白与白蛋白比率(CRP/ALB)对结直肠癌的诊断价值及与临床病理特征和生存时间的关系。方法选取86例结直肠癌患者为结直肠癌组,50例同期结直肠良性病变患者为良性病变组,50例体检健康者为对照组。检测3组血清CA19-9、ESM-1及CRP/ALB;随访结直肠癌术后患者生存情况;分析CA19-9、ESM-1、CRP/ALB对结直肠癌的诊断效能及与临床病理特征、生存时间的关系;分析患者预后危险因素。结果结直肠癌组血清CA19-9、ESM-1水平高于良性病变组、对照组,差异有统计学意义(P<0.05);结直肠癌组CRP/ALB高于良性病变组,且良性病变组高于对照组,差异有统计学意义(P<0.05)。CA19-9、ESM-1及CRP/ALB联合诊断结直肠癌的曲线下面积(AUC)为0.961,敏感度为94.18%,特异度为85.75%。CA19-9与淋巴结转移、远处转移相关(P<0.05);ESM-1与TNM分期、远处转移相关(P<0.05);CRP/ALB与肿瘤分化程度、TNM分期、淋巴结转移及远处转移相关(P<0.05)。CA19-9、ESM-1、CRP/ALB高水平患者中位生存时间分别短于CA19-9、ESM-1、CRP/ALB低水平患者,差异有统计学意义(P<0.05)。分化程度、TNM分期、远处转移、CA19-9、ESM-1、CRP/ALB为结直肠癌预后影响因素(P<0.05)。结论血清CA19-9、ESM-1及CRP/ALB联合检测对结直肠癌具有较高的诊断效能,且均与结直肠癌的发生发展密切相关,并影响患者预后。
Objective To analyze the diagnostic value of serum carbohydrate antigen 19-9(CA19-9),endothelial cell specific molecule 1(ESM-1)and ratio of C-reactive protein(CRP)to albumin(ALB)in colorectalcanceRand theiRrelationships with clinicopathological features and survival time.Methods Eighty-six patients with colorectal canceRwere selected as colorectal canceRgroup,50 patients with concurrent colorectal benign lesions were selected as benign lesion group ,and 50 healthy subjects were selected as control group .Serum CA19-9,ESM-1 and CRP/ALB in threegroups were detected;postoperative survival of colorectal canceRpatients were followed up;diagnostic efficacy of CA19-9,ESM-1,CRP/ALB in colorectal canceRand theiRrelationships with clinicopathological features and survival time were analyzed;prognostic risk factors were analyzed.Results Serum CA19-9 and ESM-1 levels in the colorectal canceRgroup were significantly higheRthan those in the benign lesion group and control group(P<0.05);the CRP/ALB in the colorectal canceRgroup was significantly higheRthan that in the benign lesion group,and was significantly higheRin the benign lesion group than that in the control group(P<0.05).The area undeRcurve(AUC)of combined diagnosis of CA19-9,ESM-1 and CRP/ALB foRcolorectal canceRwas 0.961,the sensitivity was 94.18%,and the specificity was 85.75%.CA19-9 was correlated with lymph node metastasis and distant metastasis(P<0.05);ESM-1 was correlated with TNM stage and distant metastasis(P<0.05);CRP/ALB was correlated with tumoRdifferentiation,TNM stage,lymph node metastasis and distant metastasis(P<0.05).The median survival time of patients with high levels ofCA19-9,ESM-1 and CRP/ALB was significantly shorteRthan that of patients with low levels(P<0.05).The degree of differentiation,TNM stage,distant metastasis,CA19-9,ESM-1 and CRP/ALB were prognostic influencing factors foRcolorectal canceR(P<0.05).Conclusion The joint detection of serum CA19-9,ESM-1 and CRP/ALB has a high diagnostic efficiency foRcolorectal cancer.They are all closely r
作者
潘岩
李润浦
徐洋涛
王艳丽
田志刚
马胜辉
PAN Yan;LI Runpu;XU Yangtao;WANG Yanli;TIAN Zhigang;MA Shenghui(Department of Oncology,the Second Central Hospital of Baoding City in Hebei Province,Baoding,Hebei,072750;Department of Urinary Surgery,the Second Central Hospital of Baoding City in Hebei Province,Baoding,Hebei,072750;Department of Laboratory Medicine,the Second Central Hospital of Baoding City in Hebei Province,Baoding,Hebei,072750;Department of Oncology Surgery,Chengde Central Hospital in Hebei Province,Chengde,Hebei,067000)
出处
《实用临床医药杂志》
CAS
2022年第3期95-100,共6页
Journal of Clinical Medicine in Practice
基金
2021年度河北省医学科学研究计划(20211022)。
