摘要
目的:观察参七汤对急性心肌梗死经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后患者心功能及炎性因子的影响。方法:选取2018年6月至2020年7月本院收治的急性心肌梗死PCI术后患者90例,随机分为对照组和观察组各45例。对照组采用常规西药治疗联合锻炼,观察组在对照组治疗的基础上加用参七汤,日1剂,水煎服,早晚分服。两组均治疗1个月。结果:两组患者治疗后肌钙蛋白T(Cardiac troponin T,CTnT)、肌酸磷化酶同工酶(creatine kinase isoenzymes,CK-MB)、D-二聚体均降低,左室射血分数(left ventricular ejection fraction,LVFF)升高,与治疗前比较,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05)。两组患者治疗后白细胞介素-6(interleukin 6,IL-6)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、内皮细胞特异性分子1(endothelial cell specific molecule-l,ESM-1)水平均降低,与治疗前比较,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05)。两组患者治疗后血小板计数、血小板聚集率均降低,与治疗前比较,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05)。对照组主要心血管不良事件发生率为40.00%,观察组为17.78%,两组比较,差异有统计学意义(P<0.05)。结论:参七汤可有效促进PCI术后患者心功能恢复,抑制炎性反应,降低心脏不良事件发生率。
Objective:To observe the influence of Ginseng and Sanchi Decoction on cardiac function and inflammatory factors in patients with acute myocardial infarction after percutaneous coronary intervention(PCI).Methods:A total of 90 patients with acute myocardial infarction after PCI treated in our hospital from June 2018 to July 2020 were divided into the control group and the observation group,with 45 cases in each group.The control group was treated with conventional Western medicine combined with exercise,while the observation group was treated with Ginseng and Sanchi Decoction,one dose a day,decocted in water and taken separately in the morning and evening.Both groups were treated for 1 month.Results:After treatment,cardiac troponin T(CTnT),creatine kinase isoenzymes(Ck-MB)and D-dimer decreased,and left ventricular ejection fraction(LVFF)increased in the two groups,and there were significant differences compared with those before treatment(P<0.05);there were also significant differences between the two groups(P<0.05).After treatment,the levels of interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)and endothelial cell specific molecule-1(ESM-1)decreased in the two groups,and there were significant differences compared with those before treatment(P<0.05);there were also significant differences between the two groups(P<0.05).After treatment,the levels of platelet count and platelet aggregation rate decreased in the two groups,and there were significant differences compared with those before treatment(P<0.05);there were also significant differences between the two groups(P<0.05).The incidence of major cardiovascular adverse events in the control group was 40.00%,and that in the observation group was 17.78%,and there was significant difference compared with that before treatment(P<0.05);there was also significant difference between the two groups(P<0.05).Conclusion:Ginseng and Sanchi Decoction can effectively promote the recovery of cardiac function,inhibit inflammatory reaction and reduce the incidence of ad
作者
曹云艳
CAO Yun-yan(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan,China,450000)
出处
《河南中医》
2022年第2期264-267,共4页
Henan Traditional Chinese Medicine
基金
河南省高等学校重点科研项目(20A360007)。
关键词
急性心肌梗死
经皮冠状动脉介入治疗
参七汤
阿司匹林肠溶片
氯吡格雷片
acute myocardial infarction
percutaneous coronary intervention(PCI)
Ginseng and Sanchi Decoction
Aspirin Enteric Coated Tablets
Clopidogrel Tablets
