摘要
目的:观察中西医结合疗法治疗原发性肾病综合征的临床疗效。方法:将134例原发性肾病综合征患者按照随机数字表法分为观察组和对照组,每组各67例。对照组给予口服醋酸泼尼松片治疗,观察组在对照组治疗的基础上给予口服自拟中药汤剂治疗。比较两组患者的临床疗效及治疗前后血液流变学、炎症因子[C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-8(Interleukin-8,IL-8)]、24 h尿蛋白定量、血浆白蛋白水平和不良反应发生率。结果:两组患者治疗后全血黏度(高切)、全血黏度(低切)以及纤维蛋白原低于本组治疗前,且治疗后观察组低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后血清hs-CRP、TNF-α及IL-8均低于本组治疗前,且治疗后观察组低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后24 h尿蛋白含量低于本组治疗前,且治疗后观察组低于对照组,两组患者治疗后血浆白蛋白高于本组治疗前,且治疗后观察组高于对照组,差异均有统计学意义(P<0.05)。观察组有效率为92.54%,高于对照组的80.60%,差异有统计学意义(P<0.05)。观察组不良反应发生率为13.43%,对照组不良反应发生率为16.42%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:中西医结合疗法治疗原发性肾病综合征,可改善患者血液流变学指标和炎症因子水平,促进尿蛋白和血浆白蛋白水平恢复正常。
Objective:To observe the clinical curative effect of integrated traditional Chinese and Western medicine therapy on primary nephrotic syndrome.Methods:A total of134 patients with primary nephrotic syndrome were randomly divided into the observation group and the control group,with 67 cases in each group.The control group was treated with Prednisone Acetate Tablets for oral administration,while the observation group was treated with oral self-made TCM decoction on the basis of the treatment of the control group.The clinical efficacy,the changes of inflammatory factors[including C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),Interleukin-8(IL-8)],24 h urinary protein quantification,plasma albumin level and incidence of adverse reactions before and after treatment were compared between the two groups Results:After treatment,the whole blood viscosity(high shear),whole blood viscosity(low shear)and fibrinogen in the two groups were lower than those of the same group before treatment,and the above indexes of the observation group were lower than those in the control group,and all the differences were statistically significant(P<0.05).Serum hs-CRP and TNF-αand IL-8 in the two groups after treatment were lower than those of the same group before treatment,and the above indexes of the observation group were lower than those in the control group,and all the differences were statistically significant(P<0.05).The urinary protein content of the two groups 24 hours after treatment was lower than that of the same group before treatment,and that index of the observation group was lower than that of the control group.The plasma albumin of the two groups after treatment was higher than that of the same group before treatment,and that index of the observation group after treatment was higher than that of the control group,and all the differences were statistically significant(P<0.05).The effective rate in the observation group was 92.54%,higher than 80.60%in the control group,and the difference was statistically signif
作者
孙玉锋
范立华
SUN Yu-feng;FAN Li-hua(Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China,450008)
出处
《河南中医》
2022年第2期260-263,共4页
Henan Traditional Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2019ZY2151)。
关键词
原发性肾病综合征
醋酸泼尼松片
中西医结合疗法
primary nephrotic syndrome
Prednisone Acetate Tablets
integrated traditional Chinese and Western medicine therapy
