摘要
目的探讨中性粒细胞/淋巴细胞比率(NLR)、淋巴结转移率(MLR)、血小板/淋巴细胞比率(PLR)在胃癌术后短期复发转移中的预测价值。方法选取手术治疗的胃癌患者130例,收集患者临床随访资料,检测计算NLR、MLR、PLR水平,分析其对胃癌术后复发及转移的预测价值。结果130例患者中,术后3年复发转移患者45例,复发转移率为34.62%。复发转移患者TNM分期Ⅲ期比例、中低分化比例、NLR、MLR和PLR分别为73.33%、68.89%、(2.84±0.95)、(0.47±0.12)和(165.11±63.32),明显高于无复发转移患者(P<0.05)。NLR、MLR和PLR预测胃癌术后复发转移的ROC曲线下面积为0.709、0.833和0.698,NLR、MLR和PLR截断值分别为2.45、0.31和106.36时,灵敏性分别为57.80%、87.80%和66.80%,特异性分别为78.18%、65.50%和65.50%。结论NLR、MLR、PLR在胃癌术后复发转移预测中有一定应用价值,值得进一步研究。
Objective To explore the predictive value of neutrophil/lymphocyte ratio(NLR),lymph node metastasis rate(MLR),platelet/lymphocyte ratio(PLR)in short-term recurrence and metastasis of gastric cancer after operation.Methods 130 patients with gastric cancer who underwent surgical treatment were selected and collected clinical follow-up data.Results Among 130 patients,45 had recurrence and metastasis at 3 years after operation,the recurrence and metastasis rate was 34.62%;The proportions of TNM stageⅢ,moderate to low differentiation,NLR,MLR and PLR in patients with recurrence and metastasis were 73.33%,68.89%,(2.84±0.95),(0.47±0.12)and(165.11±63.32),which were significantly higher than those in patients without recurrence and metastasis(P<0.05);The area under ROC curve of NLR,MLR and PLR for predicting recurrence and metastasis of gastric cancer after operation were 0.709,0.833 and 0.698,P<0.05,when the cut-off values of NLR,MLR and PLR were 2.45,0.31 and 106.36,the sensitivity were 57.80%,87.80%and 66.80%,the specificity were 78.18%,65.50%and 65.50%.Conclusion NLR,MLR and PLR have certain application value in predicting recurrence and metastasis of gastric cancer after operation,which is worth further study.
作者
张静
单单单
尹红梅
刘宁
李温霞
支慧
ZHANG Jing;SHAN Dandan;YIN Hongmei(Henan People's Hospital,Zhengzhou,450003)
出处
《实用癌症杂志》
2022年第3期396-398,403,共4页
The Practical Journal of Cancer
基金
河南省医学科技攻关计划(联合共建)项目(编号:LHGJ20190582)。
