摘要
目的 探讨重组人干扰素α2b凝胶联合冷冻治疗慢性宫颈炎合并HPV感染的临床效果及对患者Th17/Treg及炎性因子水平的影响。方法 择取2020年1月至12月我院收治的80例慢性宫颈炎合并HPV感染患者作为研究对象,按照治疗方案将其分为观察组(40例,重组人干扰素α2b凝胶+冷冻治疗)和对照组(40例,冷冻治疗)。比较两组的治疗效果。结果 观察组的治疗总有效率为95.00%,高于对照组的75.00%,差异具有统计学意义(P<0.05)。治疗前,两组的Th17、Treg、Th17/Treg比较,差异无统计学意义(P>0.05);治疗后,两组的Th17、Treg、Th17/Treg均较治疗前降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的IL-2、TGF-β、IL-17、IFN-γ水平比较,差异无统计学意义(P>0.05);治疗后,两组的IL-2、TGF-β、IL-17、IFN-γ水平均较治疗前降低,且观察组低于对照组(P<0.05)。治疗前,两组的SPBS-CP各维度评分比较,差异无统计学意义(P>0.05);治疗后,两组的SPBS-CP各维度评分均较治疗前降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。结论 重组人干扰素α2b凝胶联合冷冻治疗慢性宫颈炎合并HPV感染的临床效果显著,可调节机体Th17/Treg及炎性因子水平,减轻患者疾病自我感受负担,值得临床推广和应用。
Objective To explore the clinical effect of recombinant human interferon α2b gel combined with cryotherapy in the treatment of chronic cervicitis complicated with HPV infection and its influences on the Th17/Treg and inflammatory factors levels in patients. Methods A total of 80 patients with chronic cervicitis complicated with HPV infection treated in our hospital from January to December 2020 were selected as the research objects, and the patients were divided into observation group(40 cases, recombinant human interferon α2b gel + cryotherapy) and control group(40 cases,cryotherapy) according to the treatment plan. The treatment effects of the two groups were compared. Results The total effective rate of treatment in the observation group was 95.00%, which was higher than 75.00% in the control group, and the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in Th17, Treg and Th17/Treg between the two groups(P>0.05);after treatment, Th17, Treg and Th17/Treg in the two groups were lower than those before treatment, and those in the observation group were lower than the control group, the differences were statistically significant(P<0.05). Before treatment, there were no significant differences in the levels of IL-2, TGF-β,IL-17 and IFN-γ between the two groups(P>0.05);after treatment, the levels of IL-2, TGF-β, IL-17 and IFN-γ in the two groups were lower than those before treatment, and those in the observation group were lower than the control group, the differences were statistically significant(P<0.05). Before treatment, there were no significant differences in the scores of each dimension of SPBS-CP between the two groups(P>0.05);after treatment, the scores of each dimension of SPBS-CP in the two groups were lower than those before treatment, and those in the observation group were lower than the control group, the differences were statistically significant(P<0.05). Conclusion Recombinant human interferon α2b gel combined with cryotherapy in the
作者
陈美荣
CHEN Meirong(Traditional Chinese Medicine Hospital of Yintai District,Tongchuan 727000,China)
出处
《临床医学研究与实践》
2022年第10期85-88,共4页
Clinical Research and Practice
