摘要
目的:探讨多烯磷酯酰胆碱注射液联合复方甘草酸苷治疗自身免疫性肝炎(AIH)的疗效及对患者生活质量的影响。方法:选取2018年3月至2020年12月于本院消化科就诊的84例AIH患者,随机将患者分为对照组和观察组,各42例。对照组患者采用复方甘草酸苷治疗;观察组患者采用复方甘草酸苷联合多烯磷酯酰胆碱注射液治疗。疗程均为4个月。对比观察两组患者的疗效、血清趋化因子水平(CF-2、CF-8、CF-9)、免疫球蛋白水平(Ig-A、Ig-M、Ig-G)的变化以及不良反应发生率。并在治疗完成后随访半年,对比观察两组患者的生活质量水平。结果:观察组和对照组患者的治疗有效率分别为92.9%、71.4%,差异具有统计学意义(χ^(2)=6.574,P=0.010);治疗后,观察组患者的CF-2、CF-8、CF-9水平明显低于对照组(t=31.544、11.628、11.631,P=0.000、0.000、0.000);治疗后,观察组患者Ig-A、Ig-M、Ig-G水平明显低于对照组(t=4.965、11.386、4.325,P=0.000、0.000、0.000);治疗后,观察组和对照组患者的不良反应发生率分别为7.1%、23.8%,差异具有统计学意义(χ^(2)=4.459,P=0.035);经半年随访调查,观察组患者的生活质量评分(情感状态、生活满意度、工作表现与社会参与、躯体症状、认知功能)明显高于对照组(t=-5.485、-3.534、-10.091、-11.640、-11.479,P=0.000、0.001、0.000、0.000、0.000)。结论:多烯磷酯酰胆碱注射液联合复方甘草酸苷治疗AIH的临床效果佳,且能明显提高患者的生活质量。
Objective:To investigate and analyze the effect of polyenophosphoryl choline injection combined with compound glycyrrhizin in the treatment of autoimmune hepatitis(AIH) and the influence of quality of life.Methods:A total of 84 patients with AIH who were admitted to the gastroenterology department of our hospital from March 2018 to December 2020 was selected.All the patients were divided into two groups according to the method of coin toss:the control group(n=42) and the observation group(n=42).The control group was treated with compound glycyrrhizic acid,and the observation group was treated with compound glycyrrhizic acid combined with polyenophosphoryl choline.Both groups were treated for four months.The efficacy,serum chemokine levels(CF-2,CF-8,CF-9),immunoglobulin levels(Ig-A,Ig-M,Ig-G),and the incidence of adverse reactions in two groups were compared and observed.After the completion of the treatment,the patients were followed up for half a year to compare the quality of life of the two groups.Results:The effective rates of the observation group and the control group were 92.9% and 71.4%,respectively,the difference was statistically significant(χ^(2)=6.574,P=0.010).After treatment,the levels of CF-2,CF-8,and CF-9 in the observation group were significantly lower than those in the control group(t=31.544,11.628,11.631,P=0.000,0.000,0.000).After treatment,the levels of Ig-A,Ig-M,and Ig-G in the observation group were significantly lower than those in the control group(t=4.965,11.386,4.325,P=0.000,0.000,0.000).After treatment,the incidence of ADR in the observation group and the control group was 7.1% and 23.8%,respectively,the difference was statistically significant( χ2=4.459,P = 0.035).After a half-year follow-up investigation,the quality of life scores( emotional state,life satisfaction,job performance and social participation,somatic symptoms,cognitive function) in the observation group were also significantly higher than those in the control group( t =-5.485,-3.534,-10.091,-11.640,-11.479,P = 0.000,0.0
作者
冯曲波
顼国华
李莉
颜婷
FENG Qu-bo;XU Guo-hua;LI Li(Sichuan Province Forestry Center Hospital,Pharmacy Department,Chengdu,610081,China;Sichuan Province Forestry Center Hospital,Gastroenterology Department,Chengdu,610081,China)
出处
《中西医结合肝病杂志》
CAS
2022年第3期225-227,234,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
自身免疫性肝炎
多烯磷酯酰胆碱
复方甘草酸苷
疗效
生活质量
autoimmune hepatitis
polyenophosphoryl choline
compound glycyrrhizin
curative effect
quality of life
