摘要
卵黄免疫球蛋白(yolk immunoglobulin,IgY)作为禽蛋中重要的免疫活性成分,具有稳定性好、安全性高、廉价、易获得、免疫活性强、不会引发耐药性等优点,在科学研究和生产应用中表现出极强的竞争力。本文综述了IgY作为良好的抗生素替代物在病毒、细菌性疾病防治中的显著优势。另外,IgY通过特异性作用于关键限速酶、相关受体及炎症因子,在营养代谢平衡和肠道微生物菌群、免疫稳态调控中潜力巨大。合理膳食和定点递送食源性IgY可作为炎症调控、疾病防治、营养平衡和稳态调节的新方法,口服微囊化IgY包载体系有望成为解决日益剧增的突发卫生事件(如新型冠状病毒肺炎)的新途径。
As an important immuneoactive component in eggs,yolk immunoglobulin(IgY)shows great competitiveness in research and production due to its good stability,high safety,low cost,easy availability,strong immune activity,and no drug resistance.This article highlights the significant advantages of IgY as a good antibiotic substitute in the prevention and treatment of viral and bacterial diseases.Also,IgY has great potential in the regulation of nutrient metabolism balance,intestinal microflora and immune homeostasis by affecting key rate-limiting enzymes,and relevant receptors and inflammatory factors specifically.Proper diet and targeted delivery of foodborne IgY may be a new perspective on inflammation regulation,disease control,nutritional balance or homeostasis,and oral microencapsulated IgY is expected to be a new approach against increasing public health emergencies(such as COVID-19 pandemic).
作者
夏民权
李小萌
柳聪
蔡朝霞
XIA Minquan;LI Xiaomeng;LIU Cong;CAI Zhaoxia(Key Laboratory of Environment Correlative Dietology,Ministry of Education,National and Local Joint Engineering Research Center for Egg Processing Technology,College of Food Science and Technology,Huazhong Agricultural University,Wuhan 430070,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2022年第5期346-355,共10页
Food Science
基金
中央高校基本科研业务费专项资金项目(2662020SPPY005)
湖北省杰出青年基金项目(2018CFA073)。
关键词
卵黄免疫球蛋白
抗病毒
抗菌
营养代谢调节
肠道菌群稳态
yolk immunoglobulin
antiviral
antibacterial
nutrient metabolism regulation
intestinal microflora homeostasis
