摘要
表没食子儿茶素没食子酸酯[(-)-epigallocatechin-3-O-gallate, EGCG]是绿茶中含量最丰富的多酚类化合物,具有抗氧化、抗炎、抗血栓、抗辐射、抗突变、抗肿瘤、抗纤维化等广泛生物学功能,对糖尿病、肥胖、哮喘、癌症、心血管系统和神经系统疾病等有一定改善和治疗作用,亦可提高机体免疫力。近年来研究发现,EGCG在细菌、真菌、病毒、寄生虫等病原微生物引起的感染性疾病中发挥重要作用。本文就EGCG抗感染特性研究进展进行综述,以揭示其在预防和治疗感染性疾病中的潜在作用。
(-)-epigallocatechin-3-O-gallate(EGCG) is the most abundant polyphenol in green tea, which has shown antioxidant, anti-inflammatory, anti-thrombotic, anti-radiation, anti-mutant, anti-cancer and anti-fibrotic actions, and has shown improvements of diabetes, obesity, asthma, cancer, cardiovascular diseases and central nervous system disorders. In addition,EGCG is reported to enhance the human immunity. Recently, EGCG has been found to play a vital role in infectious diseases caused by pathogenic microorganisms, including bacteria, fungi, viruses and parasites. The review summarizes the progress of researches on anti-infective properties of EGCG, so as to elucidate the potential role of EGCG in the prevention and treatment of infectious diseases.
作者
杜伟勤
薛婷
DU Wei-qin;XUE Ting(Department of Medical Laboratory,the 11th Clinical Medical College,Shanxi Medical University,Lüliang,Shanxi 033000,Chi-na;National Health Commission Key Laboratory of Pneumoconiosis,Department of Respiratory and Critical Medicine,the First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China)
出处
《中国血吸虫病防治杂志》
CAS
CSCD
北大核心
2022年第1期102-108,共7页
Chinese Journal of Schistosomiasis Control
基金
山西省自然科学基金基础研究计划项目(20210302124039)
山西省高等学校科技创新项目(2020L0201,2020L0223)
山西医科大学省级博士基金项目(SD1905)
山西医科大学校级博士启动基金项目(XD1905)。
关键词
表没食子儿茶素没食子酸酯
抗感染效果
药理作用
(-)-epigallocatechin-3-O-gallate
Anti-infective activity
Pharmacological action
