摘要
目的探讨老年代谢综合征及其组分与抑郁状态的相关性。方法选取2018年3月~2019年3月接受健康体检的老年人500例,进行问卷调查,回收有效问卷468份,根据抑郁状态评估结果分为抑郁组140例和无抑郁组328例。记录两组年龄、性别、文化程度、婚姻状况等基础资料,并对其进行相关实验室指标检查[三酰甘油(TG)、空腹血糖(FPG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)]。对两组代谢综合征发生情况进行分析,探究代谢综合征与抑郁状态产生的相关性。结果抑郁组丧偶、独居、糖尿病史、代谢综合征及每周锻炼≤4h占比明显高于无抑郁组,差异均有统计学意义(P<0.05);抑郁组TG、FPG、舒张压(DBP)、收缩压(SBP)、腰围(WC)以及体质指数(BMI)高于无抑郁组患者,差异均有统计学意义(P<0.05);抑郁组腹型肥胖、高血糖、高TG血症占比高于无抑郁组,差异均有统计学意义(P<0.05);多因素logistic回归分析显示:代谢综合征、腹型肥胖、高TG血症、合并2~5个代谢综合征是老年人抑郁状态发生的独立危险因素(P<0.05)。结论老年抑郁状态人群中具有较高的代谢综合征发生率,代谢综合征与老年人抑郁情绪的发生存在密切联系,代谢综合征的发生可能会促进老年人出现抑郁状态。
Objective To investigate the association of metabolic syndrome and its components with depression in older people.Methods A total of 500 older persons undergoing health checkup from March 2018 to March 2019 were selected for questionnaire survey, 468 valid questionnaires were collected.The older persons were divided into depression group(140 cases) and depression-free group(328 cases) according to the score of depression assessment.The general data such as age, gender, educational level, marital status was recorded.The levels of triglyceride(TG),fasting plasma glucose(FPG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) were measured.The incidence of metabolic syndrome and the correlation between metabolic syndrome and depression were analyzed.Results The proportions of widowed spouse, solitary life, diabetes history, metabolic syndrome and weekly exercise≤4 h in depression group were significantly higher than those in depression-free group(P<0.05).The levels of TG and FPG,diastolic blood pressure(DBP),systolic blood pressure(SBP),waist circumference(WC) and body mass index(BMI) in depression group were higher than those in depression-free group(P<0.05).The proportions of abdominal obesity, hyperglycemia and hypertriglyceridemia in depression group were higher than those in depression-free group(P<0.05).Multivariate logistic regression analysis showed that metabolic syndrome, abdominal obesity, hypertriglyceridemia and combined with 2 to 5 metabolic syndromes were independent risk factors for depression in older persons(P<0.05).Conclusion There is a high incidence of metabolic syndrome in older persons with depression.Metabolic syndrome is closely related to depression, and may promote the occurrence of depression in older persons.
作者
杨相国
Yang Xiangguo(General Hospital of Chongqing Yongrong Mining Co.,Itd.,Chongqing 402460)
出处
《国际老年医学杂志》
2022年第2期145-148,174,共5页
International Journal of Geriatrics
