摘要
肝细胞肝癌(HCC)是一种具有高侵袭性和转移性的恶性肿瘤。采用Cox分析和Lasso回归分析逐步建立基于转移相关基因的预测模型,分析了风险评分与HCC患者的生存和临床特性的关系。构建了包含4个转移相关基因的预后模型。在TCGA训练集中,低风险组HCC患者的风险评分更低,死亡病例数更少,5年生存率更高(P<0.01),Cox分析表明该模型可独立于其他临床特征预测HCC患者的生存(P<0.01),时间依赖性ROC曲线预测分析1年、2年和3年的AUC值均大于0.74。同时,验证集获得与训练集一致的模型评估结果。最后,构建了肝癌转移相关基因的预后模型,有望成为一个独立的因素对HCC患者预后进行预测判断。
Hepatocellular carcinoma is a malignant tumor with high aggressiveness and metastasis.This study aims to construct a predictive model based on metastasis-related genes(MTGs).Cox analysis and Lasso regression analysis were used to build the prognostic model,and the relationship between the risk score of this model and the survival and clinical characteristics of hepatocellular carcinoma(HCC)patients was analyzed.The results of the study constructed a prognostic model containing four MTGs.In the the cancer genome atlas(TCGA)training set,HCC patients in the low-risk group had lower risk scores,fewer deaths and higher 5-year survival(P<0.01),Cox analysis showed that the model could predict survival of HCC patients independently of other clinical characteristics(P<0.01),and the AUC values of 1-,2-and 3-years were all greater than 0.74 in the time-dependent ROC curve prediction analysis.Meanwhile,the validation set also confirmed the above results.Taken together,we constructed a MTGs prognostic model and it was expected to be an independent prognostic factor for prognostic prediction judgment of HCC patients.
作者
刘燕群
熊蓉
肖婷
杨燕
刘康
冯刚
宋桂芹
LIU Yanqun;XIONG Rong;XIAO Ting;YANG Yan;LIU Kang;FENG Gang;SONG Guiqin(School of Basic Medicine,North Sichuan Medical College,Nanchong Sichuan 637100;Institute of Tissue Engineering and Stem Cells,The Second Clinical Medical College of North Sichuan Medical College,Nanchong Central Hospital,Nanchong Sichuan 637000;School of Medical Imaging,North Sichuan Medical College,Nanchong Sichuan 637000;Sichuan Chidingshengtong Biotechnology Co.,Ltd,Chengdu 610000)
出处
《电子科技大学学报》
EI
CAS
CSCD
北大核心
2022年第2期184-193,共10页
Journal of University of Electronic Science and Technology of China
基金
四川省科技厅科研项目(2018SZ0377,2019YFS0314)
四川省卫健委卫生健康科研课题(20PJ177)
四川省医学会科研课题(S20007)。
关键词
肝细胞肝癌
转移相关基因
预后模型
验证
hepatocellular carcinoma
metastasis-related genes
prognostic model
validation
