摘要
为了开发一种优异的用于光热治疗和光学相干层析成像的金纳米星诊疗剂,对金纳米星的制备、光热特性以及光热治疗和光学相干层析成像中的应用进行研究。利用尖端结构增强金纳米材料的局域表面等离子体共振特性,通过种子介导法制备了多枝化的金纳米星,多尖端的结构使其具有明显的光热效果,并探究了其作为光热治疗的诊疗剂和光学相干层析成像造影剂的效果。实验结果表明:多枝化的金纳米星诊疗剂相比于金纳米粒子具有较高的光热转换效率,达到42%;具有较好的生物兼容性,在100μg/mL浓度下,人乳腺癌细胞存活率为82%;而且具有较好的癌细胞光热治疗效果,在100μg/mL浓度下,经激光照射后,人乳腺癌细胞被有效杀死,其存活率降至37%;同时,金纳米星诊疗剂还具有较好的光学相干层析成像造影效果,可显著提高信号强度和造影深度。金纳米星诊疗剂既具有高效光热治疗能力,又具备优异光学相干层析成像造影成像能力,是一种非常有前景的多功能诊疗剂。
In order to develop an excellent Au nanostars therapeutic agent for photothermal therapy and op-tical coherence tomography,we research the preparation of gold nanostars,photothermal properties,photo-thermal therapy and applications in optical coherence tomography.By adopting the tip structure to enhance the local surface plasmon resonance properties of gold nanomaterials,the multi-branched Au nanostars is pre-pared by seed mediated method.The multi-tip structure enables the Au nanostars to have obvious photo-thermal effect,then its effect as a therapeutic agent for photothermal therapy and contrast agent for optical coherence tomography is explored.The experimental results showed that compared with Au nanoparticles,the multi-branched Au nanostars had a higher photothermal conversion efficiency of 42%,and has good biocompatibility.At the concentration of 100μg/mL,the survival rate of human breast cancer cells is 82%.Human breast cancer cells are effectively killed by laser irradiation at the concentration of 100μg/mL,and the survival rate is significantly reduced to 37%.At the same time,Au nanostars also has better optical coher-ence tomography imaging effect,significantly improving the signal intensity and imaging depth.Au nanostars is a promising multifunctional therapeutic agent with both efficient photothermal therapy and ex-cellent optical coherence tomography imaging capability.
作者
吴哲
陆冬筱
李金华
WU Zhe;LU Dong-xiao;LI Jin-hua(College of Physics,Changchun University of Science and Technology,Changchun 130022,China;Nanophotonics and Biophotonics Key Laboratory of Jilin Province,Changchun 130022,China)
出处
《中国光学》
EI
CAS
CSCD
北大核心
2022年第2期233-241,共9页
Chinese Optics
基金
吉林省科技发展计划项目(No.20210101155JC)
国家自然科学基金资助项目(No.62174015)
教育部“111”创新引智项目(No.D17017)
吉林省教育厅项目(No.JJKH20200730KJ,No.JJKH20210798KJ)。
关键词
金纳米星
光热治疗
光学相干层析成像
gold nanostars
photothermal therapy
optical coherence tomography
