摘要
目的:探讨参麦注射液对病毒性心肌炎患者的疗效及对血清细胞因子和心率变异性(HRV)指标的影响。方法:以丹东市第一医院2019年2月-2021年1月接收并治疗的86例病毒性心肌炎患者作为研究对象。按照随机数字表法,将患者分为对照组与观察组,每组43例。对照组患者采用常规治疗方式,观察组则在常规治疗基础上加用参麦注射液,14 d为一个疗程,共治疗一个疗程。分析两组治疗前后血清细胞因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)]、心肌损伤标志物[肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、肌红蛋白(MYO)、乳酸脱氢酶(LDH)]水平的变化,统计心率变异性指标[RR间期标准差(SDNN)、RR间期平均值标准差(SDANN)、相邻RR间期差值的均方根(RMSSD)]变化,对比两组治疗后不良反应情况。结果:治疗前,两组血清细胞因子IL-1β、IL-6以及TNF-α水平比较,差异均无统计学意义(P>0.05);治疗后,两组各项指标均降低,且观察组指标水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组心肌损伤标志物CK-MB、cTnI、MYO及LDH水平比较,差异均无统计学意义(P>0.05);治疗后,两组各项指标水平均降低,且观察组指标水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组HRV各项指标比较,差异均无统计学意义(P>0.05);治疗后,两组各项指标均升高,且观察组SDNN、SDANN及RMSSD均高于对照组(P<0.05)。治疗后随访观察2个月,两组头痛、失眠、头晕等不良反应发生情况比较,差异无统计学意义(P>0.05)。结论:参麦注射液用于病毒性心肌炎治疗中,对心肌具有保护作用,不良反应小,安全性高,改善了患者机体迷走神经功能,各项指标水平的变化可以作为临床治疗指导的参考依据。
Objective:To investigate the therapeutic effect of Shenmai Injection on patients with viral myocarditis and its effect on serum cytokines and heart rate variability (HRV).Method:A total of 86 patients with viral myocarditis admitted and treated in Dandong First Hospital from February 2019 to January 2021 were selected as the research subjects.According to the random number table method grouping principle,patients were divided into control group and observation group,with 43 cases in each group.The control group was treated with conventional treatment,while the observation group was treated with Shenmai Injection on the basis of conventional treatment,14 d as a course of treatment,for a course of treatment.The levels of serum cytokines[interleukin-1β(IL-1β),interleukin-6 (IL-6),tumor necrosis factor (TNF-α)]and myocardial injury markers[creatine kinase isoenzyme (CK-MB),cardiac troponin I (cTnI),myoglobin (MYO),lactate dehydrogenase (LDH)]in two groups were analyzed before and after treatment,the change of heart rate variability indexes (SDNN,SDANN,RMSSD) were counted,and the adverse reactions after treatment were compared between the two groups.Result:There were no significant differences in serum cytokines IL-1β,IL-6 and TNF-α between the two groups before treatment (P>0.05);after treatment,all indexes of the two groups were decreased,and those of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).There were no statistical differences in the levels of myocardial injury markers CK-MB,cTnI,MYO and LDH between the two groups before treatment (P>0.05);the levels were all decreased after treatment,those of the observation group were lower than those of the control group the control group,the differences were statistically significant (P<0.05).There were no differences in HRV indexes between the two groups before treatment (P>0.05);and they all increased after treatment,and SDNN,SDANN and RMSSD of the observation group were higher than those of
作者
崔福胜
王义文
张旭
CUI Fusheng;WANG Yiwen;ZHANG Xu(Dandong First Hospital,Liaoning Province,Dandong 118000,China;不详)
出处
《中国医学创新》
CAS
2022年第3期14-18,共5页
Medical Innovation of China
