摘要
目的观察生脉散合小柴胡汤加减联合西药对病毒性心肌炎患者的疗效及预后的影响。方法选取92例病毒性心肌炎患者,随机分为观察组与对照组各46例。对照组采用常规西医治疗,观察组在对照组基础上联合生脉散合小柴胡汤治疗,疗程4周。比较两组治疗总有效率、治疗前后的中医证候积分、血清乳酸脱氢酶(lactate dehydrogenase, LDH)、肌酸激酶(creatine kinase,CK)、肌酸激酶同功酶(creatine kinase-MB, CK-MB)水平及不良反应总发生率。结果观察组治疗总有效率为95.65%,显著高于对照组82.61%(P<0.05)。两组治疗后的中医证候积分、血清LDH、CK及CK-MB水平均较治疗前显著降低(P<0.05),且观察组降低更显著(P<0.05,P<0.01)。观察组不良反应总发生率为8.70%,对照组为4.35%,差异无统计学意义(P>0.05)。结论生脉散合小柴胡汤加减联合西药治疗病毒性心肌炎可提高治疗总有效率,改善患者证候,减轻心肌损伤,预后更佳,具有较高安全性。
Objective To observe the effect of modified Shengmai Powder-Xiaochaihu Decoction Combined with Western medicine on the outcome and prognosis of patients with viral myocarditis.Methods A total of 92 patients with viral myocarditis were randomly divided into observation group and control group(n=46 in each group).The patients in the control group received conventional Western medicine treatment,and those in the observation group were treated with Shengmai Powder-Xiaochaihu Decoction in addition to the treatment for the control group;the course of treatment was 4 weeks for both groups.The overall response rate,the improvements in traditional Chinese medicine(TCM)syndrome score and serum levels of lactate dehydrogenase(LDH),creatine kinase(CK),and creatine kinase isoenzyme(CK-MB)after treatment,and the overall incidence of adverse events were compared between the two groups.Results The observation group had a significantly higher overall response rate than the control group(95.65%vs 82.61%,P<0.05).After treatment,both groups showed significant reductions in TCM syndrome score and serum levels of LDH,CK,and CK-MB(P<0.05),and the observation group had significantly greater reductions than the control group(P<0.05,P<0.01).There was no significant difference in the overall incidence of adverse events between the observation group and the control group(8.70%vs 4.35%,P>0.05).Conclusion For patients with viral myocarditis,modified Shengmai Powder-Xiaochaihu Decoction combined with Western medicine can increase the overall response rate,improve TCM syndrome,and reduce myocardial damage,resulting in better prognosis and higher safety.
作者
姚芸
高智星
魏玉辉
YAO Yun;GAO Zhixing;WEI Yuhui(Department of Emergency,Urumqi Chinese Medicine Hospital,Urumqi,Xinjiang 830000,China)
出处
《湖南中医药大学学报》
CAS
2019年第1期90-93,共4页
Journal of Hunan University of Chinese Medicine
基金
乌鲁木齐市指导性科技计划项目(20151021035)
关键词
病毒性心肌炎
生脉散
小柴胡汤
心肌酶
viral myocarditis
Shengmai Powder
Xiaochaihu Decoction
myocardial enzyme
