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探讨拮抗剂方案中卵泡期低水平促黄体生成素对累计活产率的影响 被引量:2

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摘要 目的:探讨拮抗剂方案促排卵过程中低水平促黄体生成素(luteinizing hormone,LH)对累计活产率(cumulative live birth rate,CLBR)的影响。方法:回顾性分析本中心693例采用拮抗剂方案且首次行体外受精-胚胎移植患者的取卵周期资料,将卵泡期最低LH水平≤0.8 U/L设为A组,卵泡期最低LH水平>0.8 U/L设为B组,分析比较两组的一般临床资料、实验室指标和妊娠结局。结果:A组的基础促卵泡生成素(folliclestimulating hormone,FSH)水平、基础LH水平、人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)日LH水平显著低于B组(P<0.05)。A组的促性腺激素(gonadotropin,Gn)使用天数、HCG日雌二醇(estradiol,E2)水平、HCG日孕酮(progesterone,P)水平、获卵数、可移植胚胎数明显高于B组(P<0.05)。但两组的CLBR均无统计学差异(P>0.05)。LH水平≤0.8 U/L频次的增加对CLBR无明显影响(P>0.05)。应用多因素Logistic回归分析,调整混杂因素后,显示卵泡期最低LH水平对CLBR无明显影响,而获卵数是CLBR的独立预测因子。结论:卵泡期低水平LH可以预测更多的获卵数,但对CLBR无明显影响。
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2022年第2期211-215,共5页 Journal of Nanjing Medical University(Natural Sciences)
基金 江苏省卫计委指导性课题(LGY2018004) 南京市医学重点科技发展项目(ZKX16063)。
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