摘要
目的 探讨盐酸羟考酮注射液对结直肠癌根治术中麻醉及术后镇痛的效果。方法 72例接受腹腔镜结直肠癌根治术治疗的患者,并根据“信封法”分为对照组及观察组,每组36例。对照组患者主要应用舒芬太尼进行术中麻醉与术后镇痛,观察组患者主要应用盐酸羟考酮注射液进行术中麻醉与术后镇痛。对比两组患者不同时间点的疼痛评分及临床相关指标。结果 观察组患者拔管时(T1)、术后4 h(T2)、术后12 h(T3)、术后24 h(T4)、术后48 h(T5)时的疼痛评分分别为(1.24±0.45)、(1.11±0.36)、(1.01±0.56)、(1.05±0.33)、(0.81±0.12)分,均低于对照组的(2.77±0.68)、(2.91±0.65)、(2.12±0.72)、(1.98±0.52)、(1.55±0.15)分,差异均具有统计学意义(P<0.05)。对照组患者的拔管时间、首次肠道通气时间和镇痛泵按压次数分别为(21.51±6.33)min、(71.19±19.24)h和(3.16±1.98)次;观察组患者的拔管时间、首次肠道通气时间和镇痛泵按压次数分别为(32.69±12.11)min、(75.58±10.01)h和(0.22±0.51)次。观察组患者拔管时间长于对照组,镇痛泵按压次数少于对照组,差异均具有统计学意义(t=4.909、8.627,P=0.000、0.000<0.05)。两组患者首次肠道通气时间比较,差异无统计学意义(t=1.214, P=0.229>0.05)。结论 对结直肠癌根治术患者应用盐酸羟考酮注射液进行术中麻醉与术后镇痛效果显著,值得推广。
Objective To discuss the anesthesia and postoperative analgesia effects of oxycodone hydrochloride injection in radical resection of colorectal cancer.Methods A total of 72 patients who received laparoscopic radical resection of colorectal cancer were divided into control group and observation group according to the"envelope method",with 36 cases in each group.Patients in the control group mainly used sufentanil for intraoperative anesthesia and postoperative analgesia,while patients in the observation group mainly used oxycodone hydrochloride injection for intraoperative anesthesia and postoperative analgesia.The pain scores and clinical related indicators at different time points of the two groups were compared.Results At extubation(T1),4 h after surgery(T2),12 h after surgery(T3),24 h after surgery(T4),and 48 h after surgery(T5),the pain scores of the observation group were(1.24±0.45),(1.11±0.36),(1.01±0.56),(1.05±0.33),and(0.81±0.12)points,which were lower than(2.77±0.68),(2.91±0.65),(2.12±0.72),(1.98±0.52),and(1.55±0.15)points of the control group,and the difference was statistically significant(P<0.05).In the control group,the extubation time,first intestinal ventilation time,and number of compressions of the analgesic pump were(21.51±6.33)min,(71.19±19.24)h and(3.16±1.98)times;in the observation group,the extubation time,first intestinal ventilation time,and number of compressions of the analgesic pump were(32.69±12.11)min,(75.58±10.01)h and(0.22±0.51)times.The extubation time of the observation group was longer than that of the control group,and the number of pressings of the analgesic pump was less than that of the control group.All the differences were statistically significant(t=4.909,8.627,P=0.000,0.000<0.05).There was no statistically significant difference in first intestinal ventilation time between the two groups(t=1.214,P=0.229>0.05).Conclusion The intraoperative anesthesia and postoperative analgesia effect of oxycodone hydrochloride injection for patients undergoing radical rese
作者
倪锦萍
康利
秦洋
仲志栋
王立仁
尹述洲
NI Jin-ping;KANG Li;QIN Yang(Suzhou Kowloon Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 215000,China)
出处
《中国实用医药》
2022年第5期137-139,共3页
China Practical Medicine
关键词
盐酸羟考酮注射液
结直肠癌根治术
麻醉
术后镇痛
Oxycodone hydrochloride injection
Radical resection of colorectal cancer
Anesthesia
Postoperative analgesia
