摘要
目的分析绝经后妇女颈动脉粥样硬化状况,并探讨生殖生育因素对其颈动脉粥样硬化发病的影响。方法应用横断面调查方法,对2017年3月至2019年7月十堰市中医医院绝经后妇女进行问卷调查和超声检查。按照是否患有颈动脉粥样硬化将妇女分为两组:患有颈动脉粥样硬化妇女作为病例组;未患有颈动脉粥样硬化作为对照组。对比两组妇女社会人口学因素及生殖生育因素的差异。结果绝经后妇女颈动脉粥样硬化发病率为33.67%。高脂血症(OR=2.512,P=0.000)、初潮年龄早(OR=2.014,P=0.005)、初次分娩年龄早(OR=2.317,P=0.002)、产次多(OR=2.816,P=0.000)是绝经后妇女发生颈动脉粥样硬化的危险因素。母乳喂养时间长(OR=0.417,P=0.016)是绝经后妇女发生颈动脉粥样硬化的保护因素。受试者工作特征曲线(receiver operating characteristic curve,ROC)分析显示,初潮年龄、初次分娩年龄、母乳喂养时间等3个指标均具有一定的预测价值,ROC-曲线下面积分别为0.762、0.694、0.801。结论生殖生育因素可以影响妇女绝经后的颈动脉粥样硬化。
Objectives To analyze the status of carotid atherosclerosis in postmenopausal women and explore the effect of reproductive factors on it.Methods Cross-sectional survey was used.Questionnaire survey and ultrasonic examination were conducted on postmenopausal women from March 2017 to July 2019 in Shiyan Hospital of Traditional Chinese Medicine.The women were divided into two groups according to whether they suffered from carotid atherosclerosis or not:women with carotid atherosclerosis were as case group;women without carotid atherosclerosis were as control group.The differences of social demography factors and reproductive factors between the two groups were compared.Results The incidence of carotid atherosclerosis in postmenopausal women was 33.67%.Hyperlipidemia(OR=2.512,P=0.000),early menarche age(OR=2.014,P=0.005),early initial delivery age(OR=2.317,P=0.002)and multiple births(OR=2.816,P=0.000)were risk factors for carotid atherosclerosis in postmenopausal women.Long breast-feeding duration(OR=0.417,P=0.016)was a protective factor for carotid atherosclerosis in postmenopausal women.Receiver operating characteristic curve analysis showed that the three indexes:menarche age,age of first delivery and breast-feeding months had certain predictive value,and ROC-area under the curve(AUC)were 0.762,0.694 and 0.801,respec⁃tively.Conclusions Reproductive factors can affect carotid atherosclerosis of postmenopausal women.
作者
胡岚
陈珊珊
王燕
HU Lan;CHEN Shan-shan;WANG Yan(Department of Obstetrics and Gynecology,Shiyan Hospital of Traditional Chinese Medicine,Shiyan,Hubei 442000,China)
出处
《岭南心血管病杂志》
CAS
2022年第1期31-36,共6页
South China Journal of Cardiovascular Diseases
