摘要
过敏性休克是一种发生于对某些特定变应原有超敏反应的个体的突发且危及生命的急诊重症,特征是血管屏障破坏及血浆外渗。过敏反应及过敏性休克的治疗策略主要包括清除过敏原、动态监测生命体征、抗休克治疗(肾上腺素、液体复苏、控制血压)、抗过敏治疗。在人体内全身性过敏反应发生后10 min内血浆外渗可使全身循环血容量损失35%左右,直接导致低血容量性休克的发生,并可进一步损害全身器官功能。近年来对于血管渗漏相关病理生理机制的研究越来越广泛,通过研究以期未来能够为过敏性休克治疗提供新的思路。
Anaphylactic shock is a sudden and life-threatening emergency severe disease that occurs in individuals with primary hypersensitivity induced by certain specific changes,characterized by vascular barrier destruction and plasma exudation.The treatment strategies for anaphylactic shock mainly include removing allergens,dynamic monitoring of vital signs,antishock treatment(adrenaline,liquid resuscitation,blood pressure control),and anti-allergy therapy.In the human body,within 10 minutes of the systemic anaphylaxis,the plasma exudation can lose the systemic circulating blood volume by about 35%,which directly leads to the occurrence of hypovolemic shock,and can further damage the function of the systemic organs.In recent years,the increasing pathophysiological mechanism of vascular leakage has provided new ideas for the treatment of anaphylactic shock.
作者
杨萌
刘文操
Yang Meng;Liu Wen-cao(Shanxi Medical University,Taiyuan 030001,China)
出处
《中国急救医学》
CAS
CSCD
2022年第3期273-276,共4页
Chinese Journal of Critical Care Medicine
关键词
过敏性休克
毛细血管渗漏
肥大细胞
血管内皮细胞
低血容量性休克
Anaphylactic shock
Capillary vascular leakage
Hypertrophic cells
Vascular endothelial cells
Hypovolemic shock
