摘要
目的:观察安神补脑液辅助西药治疗双相情感障碍维持期失眠的临床疗效。方法:回顾性选取104例双相情感障碍维持期失眠患者的临床资料,根据资料中治疗方式分为对照组和观察组各52例。对照组给予常规西药治疗,观察组在对照组基础上给予安神补脑液辅助治疗。比较2组治疗前后负性情绪[汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)]、匹兹堡睡眠质量指数(PSQI)评分以及睡眠状况相关指标,评价临床疗效,观察不良反应发生情况。结果:观察组总有效率为98.08%,高于对照组82.69%,差异有统计学意义(P<0.05)。治疗后,2组HAMD、HAMA、PSQI评分较治疗前降低,且观察组HAMD、HAMA、PSQI评分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组睡眠总时间、睡眠效率均高于治疗前,夜间觉醒次数少于治疗前(P<0.05),且观察组睡眠总时间、睡眠效率均高于对照组,夜间觉醒次数少于对照组(P<0.05)。观察组不良反应发生率为7.69%,对照组为13.46%,2组比较,差异无统计学意义(χ^(2)=0.915,P=0.339)。结论:安神补脑液辅助西药治疗双相情感障碍维持期失眠患者效果确切,可明显改善患者睡眠质量和抑郁焦虑状态。
Objective: To observe the clinical effect of the therapy of Anshen Bunao liquid combined with western medicine on insomnia of bipolar disorder in maintenance period. Methods:A total of 104 clinical data of patients with insomnia of bipolar disorder in maintenance period were retrospectively selected and divided into the control group and the observation group according to the treatment methods in the data, with 52 cases in each group. The control group was treated with routine western medicine, and the observation group was additionally treated with Anshen Bunao liquid based on the treatment of the control group. Before and after treatment,the negative emotions evaluated by Hamilton Anxiety Rating Scale(HAMA) and Hamilton Rating Scale for Depression(HAMD), scores of Pittsburgh Sleep Quality Index(PSQI) and related indexes of sleep status in the two groups were compared. The clinical effects in the two groups were evaluated,and the adverse reactions were observed. Results:The total effective rate was 98.08% in the observation group,higher than that of82.69% in the control group,the difference being significant(P<0.05). After treatment,the scores of HAMD,HAMA and PSQI in the two groups were decreased when compared with those before treatment, and the above scores in the observation group were lower than those in the control group,differences being significant(P<0.05). After treatment,the total sleep time and sleep efficiency in the two groups were increased when compared with those before treatment,and the numbers of awakening at night were smaller(P<0.05);the total sleep time and sleep efficiency in the observation group were higher than those in the control group,and the number of awakening at night was smaller(P<0.05). The incidence of adverse reactions was 7.69% in the observation group, and was 13.46% in the control group, there being no significance in the difference(χ^(2)=0.915,P=0.339). Conclusion:The therapy of Anshen Bunao liquid assisting western medicine has a definite effect on patients with insomnia
出处
《新中医》
CAS
2022年第3期61-64,共4页
New Chinese Medicine
关键词
双相情感障碍
失眠
安神补脑液
碳酸锂片
富马酸喹硫平片
睡眠质量
负性情绪
Bipolar disorder
Insomnia
Anshen Bunao liquid
Lithium carbonate tablets
Quetiapine fumarate tablets
Sleep quality
Negative emotions
