摘要
目的探讨丙戊酸镁联合情景式交往训练在双相情感障碍患者中的应用效果。方法选取江西省宜春市第三人民医院2018年3月—2019年2月收治的58例双相情感障碍患者作为研究对象,采用随机数字表法分为对照组和观察组,每组各29例。对照组接受碳酸锂片治疗,观察组接受丙戊酸镁片治疗,两组均连续治疗3个月。两组患者同时在治疗期间均进行情景式交往训练。比较两组治疗后的临床疗效,治疗前后的汉密尔顿抑郁量表(HAMD)、倍克-拉范森狂躁量表(BRMS)、健康调查简表(SF-36)评分及血清尿酸(UA)、肿瘤坏死因子-α(TNF-α)及白蛋白水平。结果观察组的临床总有效率为93.10%,高于对照组的68.97%,差异有统计学意义(P<0.05)。治疗后,两组的BRMS评分、HAMD评分及血清TNF-α、UA水平均较治疗前降低,且观察组低于对照组,而SF-36评分、血清白蛋白水平均较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论丙戊酸镁联合情景式交往训练能有效降低双相情感障碍患者的抑郁、躁狂程度,抑制机体炎症反应,同时改善患者的生活质量,且临床疗效较好。
Objective To explore the application effect of Magnesium Valproate combined with situational communication training in patients with bipolar disorder.Methods A total of 58 patients with bipolar disorder in the Third People′s Hospital of Yichun,Jiangxi Province from March 2018 to February 2019 were selected as the research objects and divided into the control group and the observation group according to the random number table method,with 29 cases in each group.The control group received Lithium Carbonate Tablets for treatment,and the observation group received Magnesium Valproate Tablets for treatment.Both groups received continuous treatment for 3 months.Patients of both groups received situational communication training during treatment.The clinical efficacy after treatment between the two groups was compared,and the scores of Hamilton depression scale(HAMD),Bech-Rafaelsen mania rating scale(BRMS),and short form of 36(SF-36),the levels of uric acid(UA),tumor necrosis factor-α(TNF-α)and albumin of the two groups before and after treatment were compared.Results The total clinical effective rate in the observation group was 93.10%,which was higher than 68.97%in the control group,and the difference was statistically significant(P<0.05).After treatment,the BRMS score,HAMD score and serum TNF-αand UA levels of the two groups were lower than those before treatment,those in the observation group were lower than those in the control group,while the SF-36 score and serum albumin level were higher than those before treatment,those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Magnesium Valproate combined with situational communication training can effectively reduce the degree of depression and mania in patients with bipolar disorder,and inhibit the inflammation in the body,improve the quality of life of the patients with better clinical efficacy.
作者
万绍兰
温凉
周文琼
WAN Shao-lan;WEN Liang;ZHOU Wen-qiong(Department of Clinical Psychology,the Third People′s Hospital of Yichun,Jiangxi Province,Yichun336000,China)
出处
《中国当代医药》
CAS
2021年第22期100-102,106,共4页
China Modern Medicine
基金
江西省宜春市科技计划项目(JXYC2019KSB 073)。
关键词
双相情感障碍
丙戊酸镁
情景式交往训练
肿瘤坏死因子-α
白蛋白
尿酸
Bipolar disorder
Magnesium Valproate
Situational communication training
Tumor necrosis factor-α
Albumin
Uric acid
