摘要
目的探讨单唾液酸四己糖神经节苷脂钠注射液(GM1)致药品不良事件(ADE)的相关因素及其救护措施,为临床合理用药提供依据。方法对湖南中医药大学第一附属医院2019年1月至2020年12月发生的12例GM1致ADE报告进行回顾性分析。结果GM1致ADE多在用药后5 min~12 d内,主要表现为寒战、发热等全身性损害7例次;其余为皮肤损害3例次、呼吸系统与心血管系统损害各2例次、神经系统损害1例次,以及出现说明书未提及的视物模糊1例次,经过停药并对症处理后上述症状均明显缓解。结论临床在使用GM1前应详细询问病人过敏史,优先选择5%葡萄糖注射液做溶媒,缓慢滴注;在用药过程中应加强ADE监测,一旦发生立即停药,并考虑使用地塞米松注射剂5 mg或10 mg静滴等对症治疗。
Objective To investigate the related factors and treatment measures of adverse drug events(ADE)related to monosialo⁃tetrahexosyl ganglioside sodium injection(GM1),and to provide evidence for rational drug use in clinical practice.Methods A retro⁃spective analysis was made of 12 cases with ADE caused by intravenous infusion of GM1 reported in The First Affiliated Hospital of Hunan University of Chinese Medicine from January 2019 to December 2020.Results The ADE caused by GM1 occurred mostly with⁃in 5 min to 12 days after medication.The main manifestations were shivering,fever and other systemic damage in 7 cases.The rest were skin damage in 3 cases,respiratory system and cardiovascular system damage in respective 2 cases,nervous system damage in 1 case,and blurred vision in 1 case which was not mentioned in drug instruction.The above symptoms were obviously relieved after with⁃drawal of medication and symptomatic treatment.Conclusions Before using the injection clinically,patients should be asked about their allergy history in detail,and 5%glucose injection should be selected preferentially as solvent with slow dripping.In the process of medication,the monitoring of ADE should be strengthened.Once adverse reactions are found,the drug should be withdrawn immediate⁃ly,and symptomatic treatment such as 5 mg/10 mg intravenous drip of dexamethasone injection could be considered.
作者
肖望重
于慧
龙琼
张立委
黄莉
戴冰
XIAO Wangzhong;YU Hui;LONG Qiong;ZHANG Liwei;HUANG Li;DAI Bing(Department of Pharmacy,The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410007,China)
出处
《安徽医药》
CAS
2022年第3期633-636,共4页
Anhui Medical and Pharmaceutical Journal
基金
第四批湖南省老中医药专家学术经验继承项目(湘中医药函〔2020〕37号)
湖南省教育厅普通高等学校课程思政建设研究项目(HNKCSZ-2020-0260)
湖南省学位与研究生教育改革研究项目(2020JGZD039)
湖南省2020年一流本科课程精品在线开放课程(374)。
关键词
单唾液酸四己糖神经节苷脂钠
药品不良事件
救护措施
合理用药
Monosialotetrahexosyl ganglioside Sodium
Adverse drug events
Rescue measures
Rational administration of drug
