摘要
目的观察在单独使用左乙拉西坦和卡马西平的情况下,癫痫患者的认知功能与脑电波的治疗效果差异。方法将69例患者依据用药方法分为对照组35例与试验组34例。对照组口服卡马西平,每次100 mg,每日2次,口服;试验组口服左乙拉西坦,初始剂量为每次250 mg,4周之内逐渐增加到每次500 mg,每日2次,口服。2组治疗时间均定为6个月。对比2组的脑电图检查结果、认知功能、治疗效果、药物不良反应情况。结果治疗后,试验组和对照组的总有效率分别为100.00%(34例/34例)和94.29%(33例/35例),差异无统计学意义(P>0.05)。治疗后,试验组和对照组的棘波指数分别为(13.53±2.77)和(18.31±2.67)次·min^(-1),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的蒙特利尔认知量表(MoCA)评分分别为(27.00±2.83)和(26.56±2.49)分,差异无统计学意义(P>0.05)。试验组和对照组的药物不良反应发生率分别为14.71%(5例/34例)和37.14%(13例/35例),差异有统计学意义(P<0.05)。结论卡马西平、左乙拉西坦对癫痫患者的认知功能改善效果相似,但左乙拉西坦对脑电波的改善效果更佳,且药物不良反应发生率更低。
Objective To observe the difference of cognitive function and EEG treatment effect in epilepsy patients using levetiracetam and carbamazepine alone.Methods The 69 patients were divided into 35 cases in the control group and 34 cases in the treatment group according to the medication method.The control group was taken orally with carbamazepine,100 mg each time,2 times a day,orally;the treatment group was taken orally with levetiracetam,the initial dose was 250 mg each time,and gradually increased to 500 mg each time within 4 weeks 2 times,orally.The treatment time for both groups was set at 6 months.Compare the EEG examination results,cognitive function,treatment effect,and adverse drug reactions of the two groups.Result After treatment,the total effective rates of the treatment group and the control group were 100.00%(34 cases/34 cases)and 94.29%(33 cases/35 cases),with no significant difference(P>0.05).After treatment,the spike wave index of the treatment group and the control group were(13.53±2.77)and(18.31±2.67)times·min^(-1),with statistically significant difference(P<0.05).After treatment,the Montreal Cognitive Scale(MoCA)scores of the treatment group and the control group were 27.00±2.83 and 26.56±2.49,with no statistically significant difference(P>0.05).The adverse drug reactions of the treatment group mainly included skin rash,leukopenia,thrombocytopenia,and headache.The incidence of adverse drug reactions in the treatment group and the control group were 14.71%(5 cases/34 cases)and37.14%(13 cases/35 cases),with statistically significant difference(P<0.05).Conclusion The efficacy of carbamazepine and levetiracetam on the recognition funtion in patients with epilepsy were similar,while levetiracetam exerted more significant efficacy on brain wave with lower incidence of adverse reactions.
作者
张天照
ZHANG Tian-zhao(Department of Neurology,Chengdu 363 Hospital,Chengdu 610041,Sichuan Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2021年第8期962-965,共4页
The Chinese Journal of Clinical Pharmacology
关键词
左乙拉西坦
卡马西平
癫痫
认知功能
脑电波
levetiracetam
carbamazepine
epilepsy
cognitive function
brain wave
