摘要
目的:分析玄参“发汗”前后的化学成分、药理作用和“发汗”工艺,为玄参的加工、临床应用和进一步研究提供参考。方法:以“玄参”、“炮制”、“发汗”、“化学成分”、“药理作用”等作为关键词,搜索各大数据库的相关文献,查阅相关专业书籍,系统整理并进行综述。结果和结论:经“发汗”后,玄参的化学成分中,环烯醚萜类总量下降,其中的哈巴苷和哈巴俄苷变化不大,类叶升麻苷、安格洛苷C和毛蕊花糖苷含量明显上升,多糖类与DNA含量下降。在药理作用中,抗炎和镇痛作用明显增强,免疫作用轻度增强。在“发汗”工艺上,以完整主根为原料,经过35℃烘箱干燥的处理手段,发汗3 d的方式,核苷类成分含量最高;微波真空干燥下,干燥温度60℃,干燥3.5 h条件下,得到的哈巴苷和哈巴俄苷含量最多。
Objective:To analyze the chemical constituents,pharmacological effects and"sweating"technology of Radix Scrophulariae before and after"sweating",so as to provide reference for the processing,clinical application and further research of Radix Scrophulariae.Methods:With"Radix Scrophulariae","processing","sweating","chemical composition"and"pharmacological action"as key words,the relevant literature of each knowledge platform was searched,the relevant research books were consulted,all the data was systematically sorted out and summarized.Results&Conclusion:After"sweating",the total content of iridoids in the chemical components of Radix Scrophulariae decreased,and the contents of habaside and habasiosidechange little.The contents of cimicifugin,angloride C and Mullein glycoside increased significantly,while the contents of polysaccharides and DNA decreased.In terms of pharmacological effects,the anti-inflammatory and analgesic effects were significantly enhanced,and the immune effect was slightly enhanced.In the"sweating"process,the complete taproot was used as raw material and dried in the oven at 35°C.The content of nucleosides was the highest in the way of sweating for 3 days;Under the condition of microwave vacuum drying,drying temperature 60°C and drying time 3.5 h,the contents of harpagoside and harpagoside were the highest.
作者
代琪
樊白月
叶俏波
罗霄
雷蕾
杨江媛
DAI Qi;FAN Bai-yue;YE Qiao-bo;LUO Xiao;LEI Lei;YANG Jiang-yuan(Chengdu Institute for Drug Control,NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine,Sichuan Chengdu 610045,China;Clinical Medical Collage,Chendu University of Medicine,Sichuan Chengdu 611137,China;Basic Medical College,Chengdu University of Traditional Chinese Medicine,Sichuan Chengdu,611137,China;Yunnan Provincial Hospital of Traditional Chinese Medicine,Yunnan Kunming 650021,China)
出处
《中国药物评价》
2022年第1期41-43,共3页
Chinese Journal of Drug Evaluation
基金
四川药品监督管理局科技计划项目(2021005)、四川省国际科技创新合作/港澳台科技创新合作项目(2020YFH0193)、国家中管局:2018级全国中药特色技术传承人才培训项目(T20184828005)。
关键词
玄参
炮制
发汗
化学成分
药理作用
Radix Scrophulariae
Processing
Sweating
Chemical composition
Pharmacological action
