摘要
目的观察尼可地尔治疗微血管性心绞痛的有效性并评估其应用价值。方法选择2019年6月—2021年6月期间就诊于该院心内科的120例微血管性心绞痛患者,对其临床资料进行回顾性分析,将采取常规内科治疗的60例患者归入对照组,将加用尼可地尔的60例患者归入研究组。组间对比临床疗效,不良反应发生率,治疗前后的内皮素-1、一氧化氮、C-反应蛋白水平。结果研究组的总有效率(93.33%)高于对照组(66.67%),差异有统计学意义(χ^(2)=13.333,P<0.001)。研究组的不良反应发生率(6.67%)与对照组(10.00%)相近,差异无统计学意义(χ^(2)=0.436,P>0.05)。研究组治疗前的内皮素-1、一氧化氮、C-反应蛋白水平分别为(144.23±16.55)μmol/L、(39.94±5.45)μmol/L、(12.44±2.62)mg/L,与对照组的(144.74±16.63)μmol/L、(39.37±5.81)μmol/L、(12.38±2.71)mg/L相近,差异无统计学意义(t=0.168、0.554、0.123,P>0.05)。治疗后,研究组的内皮素-1、一氧化氮、C-反应蛋白水平分别为(90.57±10.29)μmol/L、(80.71±7.96)μmol/L、(6.47±0.94)mg/L,优于对照组的(120.72±12.56)μmol/L、(53.51±6.48)μmol/L、(9.52±1.43)mg/L,差异有统计学意义(t=14.383、20.527、13.806,P<0.001)。结论尼可地尔对微血管性心绞痛有比较显著的安全性和有效性,可改善患者血管内皮功能,其应用价值很高。
Objective To observe the effectiveness of nicorandil in the treatment of microvascular angina pectoris and evaluate its application value.Methods A total of 120 patients with micro vascular angina who were admitted to the cardiology department of the hospital from June 2019 to June 2021 were selected.A retrospective analysis of its clinical data,60 patients who received conventional medical treatment were included in the control group,and 60 patients who received nicorandil were included in the study group.The clinical efficacy,incidence of adverse reactions,levels of endothelin-1,nitric oxide and C-reactive protein before and after treatment were compared between the groups.Results The total effective rate of the study group(93.33%) was higher than that of the control group(66.67%),and the difference was statistically significant(χ^(2)=13.333,P<0.001).The incidence of adverse reactions in the study group(6.67%) was similar to that in the control group(10.00%),and the difference was statistically significant(χ^(2)=0.436,P>0.05).The levels of endothelin-1,nitric oxide and C-reactive protein before treatment in the study group were(144.23±16.55) μmol/L,(39.94±5.45) μmol/L,and(12.44±2.62) mg/L,respectively.Similar to the control group(144.74±16.63) μmol/L,(39.37±5.81) μmol/L,and(12.38±2.71) mg/L,the difference was not statistically significant(t=0.168,0.554,0.123,P>0.05).After treatment,the levels of endothelin-1,nitric oxide,and C-reactive protein in the study group were(90.57±10.29) μmol/L,(80.71±7.96) μmol/L,and(6.47±0.94) mg/L,respectively,better than the control group(120.72±12.56) μmol/L,(53.51±6.48) μmol/L,(9.52±1.43) mg/L,and the difference was statistically significant(t=14.383,20.527,13.806,P<0.001).Conclusion Nicorandil has significant safety and effectiveness for microvascular angina pectoris.It can improve the vascular endothelial function of patients,and its application value is very high,which should be actively used for patients in clinical application.
作者
秦鹏
QIN Peng(Department of Cardiology,Beijing Yanhua Hospital,Beijing,102500 China)
出处
《世界复合医学》
2021年第12期148-151,共4页
World Journal of Complex Medicine
关键词
尼可地尔
微血管性心绞痛
有效性
血管内皮功能
安全性
应用价值
Nicorandil
Microvascular angina pectoris
Effectiveness
Vascular endothelial function
Safety
Application value
