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吡非尼酮在皮肌炎并肺间质纤维化中的治疗作用 被引量:1

Therapeutic effect of pirfenidone in dermatomyositis with pulmonary interstitial fibrosis
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摘要 目的 观察吡非尼酮在皮肌炎并肺间质变中的治疗效果。方法 选取2017年1月至2019年12月本院收治的72例皮肌炎并肺间质纤维化患者作为研究对象,随机分为治疗组(n=40)和对照组(n=32)。治疗组采用激素和免疫抑制剂联合吡非尼酮治疗,对照组采用激素和免疫抑制剂治疗。比较两组治疗前及治疗后3、6、12个月的血清KL-6水平、胸部高分辨CT和肺功能。结果 治疗后3、6、12个月,对照组KL-6水平与治疗前比较差异无统计学意义,治疗组KL-6水平均低于治疗前(P<0.05),且治疗组低于对照组(P<0.05);治疗组胸部高分辨CT和肺功能较治疗前显著改善,对照组胸部高分辨CT和肺功能无明显改善。结论 吡非尼酮吡能阻止皮肌炎的肺间质纤维化的发展,并改善肺间质纤维化和肺功能。 Objective To observe the effect of pirfenidone in the treatment of dermatomyositis with pulmonary interstitial fibrosis.Methods 72 patients with dermatomyositis complicated pulmonary interstitial fibrosis from January 2017 to December 2019 were selected as study subjects,and they were randomly divided into treatment group(n=40) and control group(n=32).The treatment group was treated with corticosteroid and immunosuppressant combined with pirfenidone,while the control group was treated with corticosteroid and immunosuppressant.The levels of serum KL-6,HRCT and pulmonary function were compared between two groups before treatment and 3,6 and 12 months after treatment.Results 3,6,and 12 months after treatment,the level of KL-6 in the control group was not significantly different from that before treatment,and the KL-6 level in the treatment group was lower than before treatment(P<0.05),and the treatment group was lower than the control group(P<0.05),the HRCT and pulmonary function of the treatment group were improved,but the HRCT and pulmonary function were not significantly improved in the control group.Conclusion Pirfenidone prevents the development of pulmonary interstitial fibrosis of dermatomyositis,and improves pulmonary interstitial fibrosis and pulmonary function.
作者 张佳林 陈少英 ZHANG Jialin;CHEN Shaoying(Department of Rheumatology,Zhangzhou Hospital Affiliated to Fujian Medical University,Zhangzhou,Fujian,363000,China)
出处 《当代医学》 2022年第8期12-15,共4页 Contemporary Medicine
关键词 吡非尼酮 皮肌炎 肺间质纤维化 Pirfenidone Dermatomyositis Pulmonary interstitial fibrosis
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