摘要
目的:探讨化痰解郁安神汤治疗失眠伴抑郁症的临床疗效。方法:选择2019年5月至2021年5月新余北湖医院收治的失眠伴抑郁症患者94例,根据随机数字表法将患者分为两组,各47例。对照组予以常规阿普唑仑、米氮平治疗,在此基础上,研究组加用化痰解郁安神汤治疗。连续治疗4周后,比较两组临床疗效、睡眠质量、抑郁程度、不良反应。结果:相较于对照组,研究组总有效率高,差异有统计学意义(P<0.05);两组治疗4周后匹茨堡睡眠质量指数量表(PSQI)评分均下降,且相较于对照组,研究组PSQI评分低,差异有统计学意义(P<0.05);两组治疗4周后汉密顿抑郁量表(HAMD)评分均下降,且相较于对照组,研究组HAMD评分低,差异有统计学意义(P<0.05);研究组不良反应发生率较对照组略低,但差异无统计学意义(P>0.05)。结论:化痰解郁安神汤治疗失眠伴抑郁症患者可提高临床疗效,改善睡眠质量和抑郁程度,且安全性较高。
Objective:To explore the clinical effect of huatan jieyu anshen decoction on insomnia and depression.Methods:94 patients with insomnia and depression admitted to Xinyu Beihu Hospital from May 2019 to May 2021 were selected.The patients were divided into two groups according to the random number table method,47 cases in each group.The control group was treated with alprazolam and mirtazpine,and on this basis,the study group was treated with huatan jieyu anshen decoction.After continuous treatment for 4 weeks,clinical efficacy,sleep quality,depression degree and adverse reactions were compared between the two groups.Results:Compared with the control group,the total effective rate of the study group was higher,the difference was statistically significant(P<0.05);after 4 weeks of treatment,the Pittsburgh sleep quality index(PSQI)score of both groups decreased,and compared with the control group,the PSQI score of the study group was lower,the difference was statistically significant(P<0.05);after 4 weeks of treatment,the HAMD score of both groups decreased,and compared with the control group,the HAMD score of the study group was lower,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was slightly lower than that in the control group,but there was no statistical significance(P>0.05).Conclusion:Huatan jieyu anshen decoction can improve the clinical efficacy,sleep quality and depression degree of insomnia patients with depression,and has high safety.
作者
吴涛
WU Tao(Xinyu Beihu Hospital,Xinyu Jiangxi 338000,China)
出处
《药品评价》
CAS
2022年第1期45-47,共3页
Drug Evaluation
关键词
失眠
抑郁症
化痰解郁安神汤
睡眠质量
阿普唑仑
米氮平
Insomnia
Depression
Huatan jieyu anshen decoction
The quality of sleep
Alprazolam
Mirtazapine
