摘要
细胞蛇是近年来细胞生物学研究的热门方向之一,由于其在细胞的增殖、代谢和发育上具有一定的生物学功能,因此,对一些疾病如癌症等的临床诊断或治疗具有一定的指导意义。细胞蛇是由三磷酸胞苷合成酶(cytidine triphosphate synthetase, CTPS)聚合而成的无膜细胞器,其形成过程及功能在不同类型的细胞中不尽相同。例如:细胞蛇能促进癌细胞增殖,并使患者病情恶化;过表达的细胞蛇可抑制神经干细胞增殖,影响大脑皮层发育;在卵泡细胞中,细胞蛇相当于CTPS的存储库,在卵子发生过程起到促进细胞增殖和代谢的作用。本文就细胞蛇的形成过程及其在不同类型细胞中的功能进行阐述,以期人们进一步认识细胞蛇,并探索其潜在作用机制和应用价值。
The cytoophidium is one of the most popular research topics in cell biology. It has guiding significance for clinical diagnosis or treatment because of its biological functions in cell proliferation, metabolism and development. The cytoophidium is a membrane-free organelle polymerized by cytidine triphosphate synthetase(CTPS), and its formation process and functions are not the same in different types of cells. It can promote the cancer cell proliferation and lead to disease deterioration. In neural stem cells, cytoophidium overexpression can inhibit the cell proliferation and affect the development of cerebral cortex. And in ovarian follicular cells, the cytoophidium acts as a CTPS repository to increase the cell proliferation and metabolism during oogenesis. Herein, novel findings on the formation process and functions of cytoophidium in different types of cells are summarized for further exploring its potential mechanisms and application value.
作者
李欣玲
张樱馨
李进兰
潘文鑫
王彦凤
杨丽蓉
王通
俞晓丽
LI Xin-ling;ZHANG Ying-xin;LI Jin-lan;PAN Wen-xin;WANG Yan-feng;YANG Li-rong;WANG Tong;YU Xiao-li(Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education,College of Clinical Medical Sciences,College of Basic Medical Sciences,Ningxia Medical University,Yinchuan 750000,Ningxia,China)
出处
《生命科学研究》
CAS
CSCD
2022年第1期54-58,75,共6页
Life Science Research
基金
宁夏自然科学基金项目(2020AAC03179)
国家自然科学基金资助项目(31560329)。
